Evidence map›Paper›PMID 38846937›Full record

ArticleFrontiers in immunology2024

Exosomes derived from miR-146a-overexpressing fibroblast-like synoviocytes in cartilage degradation and macrophage M1 polarization: a novel protective agent for osteoarthritis?

Huan Wang, Yue Zhang, Chengfei Zhang, Yan Zhao, Jun Shu, Xuezhang Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huan WangDepartment of Traditional Chinese Medicine Massage, China-Japan Friendship Hospital, Beijing, China.
Yue ZhangSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Chengfei ZhangDepartment of Endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Yan ZhaoDepartment of Subhealth, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Jun ShuInstitute of Clinical Research, China-Japan Friendship Hospital, Beijing, China.
Xuezhang TangDepartment of Traditional Chinese Medicine Massage, China-Japan Friendship Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Pathological changes in the articular cartilage (AC) and synovium are major manifestations of osteoarthritis (OA) and are strongly associated with pain and functional limitations. Exosome-derived microRNAs (miRNAs) are crucial regulatory factors in intercellular communication and can influence the progression of OA by participating in the degradation of chondrocytes and the phenotypic transformation in the polarization of synovial macrophages. However, the specific relationships and pathways of action of exosomal miRNAs in the pathological progression of OA in both cartilage and synovium remain unclear. Methods: This study evaluates the effects of fibroblast-like synoviocyte (FLS)-derived exosomes (FLS-Exos), influenced by miR-146a, on AC degradation and synovial macrophage polarization. We investigated the targeted relationship between miR-146a and TRAF6, both Results: The expression of miR-146a in the synovial exosomes of OA rats was significantly higher than in healthy rats. Discussion: These findings suggest that miR-146a, mediated through FLS-Exos, may alleviate OA progression by modulating cartilage degradation and macrophage polarization, implicating the NF-κB pathway in the innate immune response. These insights highlight the therapeutic potential of miR-146a as a protective agent in OA, underscoring the importance of exosomal miRNAs in the pathogenesis and potential treatment of the disease.

Indexed as

ExosomesMacrophagesMicroRNAsOsteoarthritisSynoviocytesTNF Receptor-Associated Factor 6AnimalsApoptosisCartilage, ArticularCells, CulturedChondrocytesFibroblastsMacrophage ActivationNF-kappa BRatsRats, Sprague-DawleyMicroRNAsMIRN146a microRNA, ratNF-kappa BTNF Receptor-Associated Factor 6Toll-Like Receptor 4cartilage degradationexosomemacrophage polarizationmiR-146aosteoarthritis

Identifiers

PMID38846937
PMCPMC11153682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.