Trial reportFrontiers in public health2024
Effects of Baduanjin exercise on cognitive frailty, oxidative stress, and chronic inflammation in older adults with cognitive frailty: a randomized controlled trial.
Trial report in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Integrating exercise and nutrition to combat frailty: a systematic review of multidomain interventions in aging populations.Frontiers in nutrition · 2026Pooled it
- Effects of Health Qigong on quality of life, physical function, and mental health in older adults: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Rethinking exercise dose for cognitive ageing: a systematic review and meta-analysis of physical dose and cognitive-motor demands.Frontiers in psychology · 2026Pooled it
- Effects of Baduanjin exercise on cognitive impairment in older adults: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Optimal doses of mind-body exercise on neuroinflammation in individuals with neuropsychiatric disorders: A systematic review and dose-response meta-analysis.Brain, behavior, & immunity - health · 2026Article
- Progress in research on cognitive frailty in the older adults: a narrative review.Frontiers in medicine · 2026Review
- Effects of standing Baduanjin exercise on cardiac function and quality of life in patients with chronic heart failure: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Review
- Effects of qigong and resistance exercise on improving balance and cognitive ability of community-dwelling older adults.Frontiers in public health · 2026Article
- Health Qigong engagement scale and wellbeing in Chinese older adults.Frontiers in public health · 2026Article
- Redox regulation in aging muscles: exercise as a key modulator to combat sarcopenia and frailty.Frontiers in cell and developmental biology · 2026Review
- Four-Limb Coordinated Training and Neuroplasticity in Older Adults with Cognitive Frailty: Mechanisms and Clinical Evidence.Clinical interventions in aging · 2026Review
- Interaction Between Smoking and Olfactory Function on Frailty: A Population-Based Cross-Sectional Study.Health science reports · 2025Article
- Article
- The Effects of Physical Activity on Skin Health: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2025Review
- Aerobic exercise-induced lactate production: a novel opportunity for remodeling the tumor microenvironment.Frontiers in genetics · 2025Review
- The impact of exercise interventions on cognitive frailty: a scoping review of outcomes and biological mechanisms.Frontiers in public health · 2025Article
- The Effect of Exercise Program Interventions on Frailty, Clinical Outcomes, and Biomarkers in Older Adults: A Systematic Review.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oxidative stress and chronic inflammation play an important role in the pathogenesis process of cognitive frailty (CF). Regular Baduanjin exercise could improve cognitive frailty in older adults, but it is unclear whether the effect of Baduanjin exercise on improving CF is mediated by modulating circulating oxidative stress and inflammatory process. Method: A total of 102 community-dwelling older adults with CF were recruited and randomly allocated into a 24-week Baduanjin exercise training group or no specific exercise intervention control group at an equal rate. Cognitive function and physical frailty index were assessed using the Montreal Cognitive Assessment (MoCA) and the Edmonton Frail Scale (EFS), as well as the oxidative stress and inflammatory cytokines were measured at baseline and after intervention. Result: After 24 weeks of intervention, the increased MoCA score (2.51 ± 0.32 points, Conclusion: Regular Baduanjin exercise training could improve the cognitive frailty of the community-dwelling older adults with CF, and modulate oxidative stress and inflammatory processes by reducing circulating pro-oxidative MDA and 8-iso-PGF2α levels and increasing anti-oxidative SOD levels, as well as impacting inflammatory cytokines IFN-γ, IL-2, and IL-4 levels. Nevertheless, the mechanism of Baduanjin exercise mediating oxidative stress and inflammatory processes should be cautious to be explained. Clinical trial registration: http://www.chictr.org.cn/index.aspx, ChiCTR1800020341.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.