Evidence map›Paper›PMID 38846405›Full record

ArticleChemical science2024

Periodic table screening for enhanced positive contrast in MRI and

Aitor Herraiz, M Puerto Morales, Lydia Martínez-Parra, Nuria Arias-Ramos, Pilar López-Larrubia, Lucía Gutiérrez, Jesús Mejías, Carlos Díaz-Ufano, Jesús Ruiz-Cabello, Fernando Herranz

Abstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aitor HerraizGrupo de Nanomedicina e Imagen Molecular, Instituto de Química Médica (IQM/CSIC) Juan de la Cierva 3 28006 Madrid Spain fherranz@iqm.csic.es.
M Puerto MoralesDepartamento de Nanociencia y Nanotecnología, Instituto de Ciencia de Materiales de Madrid, CSIC Sor Juana Inés de la Cruz 3. Cantoblanco 28049 Madrid Spain.ORCID https://orcid.org/0000-0002-7290-7029
Lydia Martínez-ParraCIC biomaGUNE, Basque Research and Technology Alliance (BRTA, ) Paseo de Miramon 182 20014 Donostia San Sebastián Spain.
Nuria Arias-RamosInstituto de Investigaciones Biomédicas Sols-Morreale (IIBM), CSIC-UAM Madrid Spain.
Pilar López-LarrubiaInstituto de Investigaciones Biomédicas Sols-Morreale (IIBM), CSIC-UAM Madrid Spain.
Lucía GutiérrezDepartamento de Química Analítica, Instituto de Nanociencia y Materiales de Aragón. Universidad de Zaragoza y CIBERBBN Mariano Esquillor s/n 50018 Zaragoza Spain.ORCID https://orcid.org/0000-0003-2366-3598
Jesús MejíasGrupo de Nanomedicina e Imagen Molecular, Instituto de Química Médica (IQM/CSIC) Juan de la Cierva 3 28006 Madrid Spain fherranz@iqm.csic.es.
Carlos Díaz-UfanoDepartamento de Nanociencia y Nanotecnología, Instituto de Ciencia de Materiales de Madrid, CSIC Sor Juana Inés de la Cruz 3. Cantoblanco 28049 Madrid Spain.
Jesús Ruiz-CabelloCIC biomaGUNE, Basque Research and Technology Alliance (BRTA, ) Paseo de Miramon 182 20014 Donostia San Sebastián Spain.
Fernando HerranzGrupo de Nanomedicina e Imagen Molecular, Instituto de Química Médica (IQM/CSIC) Juan de la Cierva 3 28006 Madrid Spain fherranz@iqm.csic.es.ORCID https://orcid.org/0000-0002-3743-0050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The quest for nanomaterial-based imaging probes that can provide positive contrast in MRI is fueled by the necessity of developing novel diagnostic applications with potential for clinical translation that current gold standard probes cannot provide. Although interest in nanomaterials for positive contrast has increased in recent years, their study is less developed than that of traditional negative contrast probes in MRI. In our search for new magnetic materials with enhanced features as positive contrast probes for MRI, we decided to explore the chemical space to comprehensively analyze the effects of different metals on the performance of iron oxide nanomaterials already able to provide positive contrast in MRI. To this end, we synthesized 30 different iron oxide-based nanomaterials. Thorough characterization was performed, including multivariate analysis, to study the effect of different variables on their relaxometric properties. Based on these results, we identified the best combination of metals for

Identifiers

PMID38846405
PMCPMC11151829

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.