Evidence map›Paper›PMID 38846385›Full record

ArticleChemical science2024

Zinc chloride-catalyzed Grignard addition reaction of aromatic nitriles.

Manabu Hatano, Kisara Kuwano, Riho Asukai, Ayako Nagayoshi, Haruka Hoshihara, Tsubasa Hirata, Miho Umezawa, Sahori Tsubaki, Takeshi Yoshikawa, Ken Sakata

Abstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manabu HatanoFaculty of Pharmaceutical Sciences, Kobe Pharmaceutical University Higashinada Kobe 658-8558 Japan mhatano@kobepharma-u.ac.jp.ORCID https://orcid.org/0000-0002-5595-9206
Kisara KuwanoFaculty of Pharmaceutical Sciences, Kobe Pharmaceutical University Higashinada Kobe 658-8558 Japan mhatano@kobepharma-u.ac.jp.
Riho AsukaiFaculty of Pharmaceutical Sciences, Kobe Pharmaceutical University Higashinada Kobe 658-8558 Japan mhatano@kobepharma-u.ac.jp.
Ayako NagayoshiFaculty of Pharmaceutical Sciences, Kobe Pharmaceutical University Higashinada Kobe 658-8558 Japan mhatano@kobepharma-u.ac.jp.
Haruka HoshiharaFaculty of Pharmaceutical Sciences, Kobe Pharmaceutical University Higashinada Kobe 658-8558 Japan mhatano@kobepharma-u.ac.jp.
Tsubasa HirataFaculty of Pharmaceutical Sciences, Kobe Pharmaceutical University Higashinada Kobe 658-8558 Japan mhatano@kobepharma-u.ac.jp.ORCID https://orcid.org/0000-0002-3385-0285
Miho UmezawaFaculty of Pharmaceutical Sciences, Toho University Miyama, Funabashi Chiba 274-8510 Japan takeshi.yoshikawa@phar.toho-u.ac.jp ken.sakata@phar.toho-u.ac.jp.
Sahori TsubakiFaculty of Pharmaceutical Sciences, Toho University Miyama, Funabashi Chiba 274-8510 Japan takeshi.yoshikawa@phar.toho-u.ac.jp ken.sakata@phar.toho-u.ac.jp.
Takeshi YoshikawaFaculty of Pharmaceutical Sciences, Toho University Miyama, Funabashi Chiba 274-8510 Japan takeshi.yoshikawa@phar.toho-u.ac.jp ken.sakata@phar.toho-u.ac.jp.ORCID https://orcid.org/0000-0002-7489-5252
Ken SakataFaculty of Pharmaceutical Sciences, Toho University Miyama, Funabashi Chiba 274-8510 Japan takeshi.yoshikawa@phar.toho-u.ac.jp ken.sakata@phar.toho-u.ac.jp.ORCID https://orcid.org/0000-0002-6920-0735

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the alkyl addition reaction of aromatic nitriles using Grignard reagents, ketones are formed after hydrolysis. However, this addition reaction is often slow compared to that using reactive organolithium(i) reagents. In this study, we improved the reaction by using zinc(ii)ates, which are generated

Identifiers

PMID38846385
PMCPMC11151835

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.