SynthesisFrontiers in oral health2024
The association between betel quid use and oral potentially malignant and malignant disorders in Southeast Asian and Pacific regions: a systematic review and meta-analysis with GRADE evidence profile.
Synthesis in Frontiers in oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Early-Onset Oral Squamous Cell Carcinoma: Emerging Biological Insights, Risk Factors and Clinical Implications.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Review
- Understanding betel nut addiction: a review of harmful consequences, underlying neurobiology, and emerging intervention strategies.Translational psychiatry · 2026Review
- 2-O-Methylmagnolol suppresses oral squamous cell carcinoma progression by targeting c-MYC signaling.Journal of dental sciences · 2026Article
- Tempeh Extract and HSC-3 Cell Migration: An In Vitro Study.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Optimizing Oral Cancer Screening: Latent Class Analysis of Chairside Adjuncts in a High-Risk Dental Cohort.Cureus · 2025Article
- Patterns of oral squamous cell carcinoma among smokeless tobacco users: A clinical study.Bioinformation · 2025Article
- The Impact of Electronic and Conventional Cigarette Use towards Saliva Profile and Oral Microbiota in Adolescents.Asian Pacific journal of cancer prevention : APJCP · 2025Observational
- Artificial intelligence-driven clinical decision support systems for early detection and precision therapy in oral cancer: a mini review.Frontiers in oral health · 2025Review
- Global burden of head and neck cancer: Epidemiological transitions, inequities, and projections to 2050.Frontiers in oncology · 2025Article
- Role of optical imaging in oral cancer and oral potentially malignant disorders: implications for oral submucous fibrosis.Frontiers in oral health · 2025Review
- Salivary Profile Analysis Based on Oral Cancer Risk Habits: An Observational Cross-Sectional Study.Biomedicines · 2024Article
- ABO Blood Groups as Predictors of Oral Malignancy Risk - A Retrospective Study.Annals of maxillofacial surgeryArticle
- Salivary SIRT3 Levels in Gutka and Alcohol Consumers: A Cross-Sectional Study on Habit-Associated Molecular Changes.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Betel quid (BQ) chewing is a prevalent habit in the Asian and Pacific regions. It is deeply intertwined within cultural customs, and has been reported to result in oral potentially malignant disorders (OPMDs) and malignant disorders (MDs). Objective: We aim to present a summative and broad overview of the burden that BQ chewing has imposed on the residents of the Southeast Asian, Pacific, and Australasian regions, allowing us to quantify the level of impact it is currently causing on the risk of people developing oral cancer. Methods: This scoping review and meta-analysis screened databases such as PubMed, MEDLINE, and Google Scholar for publications that investigated the association between BQ and OPMDs and MDs. The search strategy involved MeSH headings relating to BQ, OPMDs, and MDs, and a search for results during the period between January 2010 and June 2023 within the set geographical boundaries of the Southeast Asian and Pacific regions. This systematic review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement for Scoping Reviews (PRISMA-ScR). R software was used to screen outliers. The included studies were further analysed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: Nine articles ( Discussion: A meta-analysis of two outcomes revealed substantial heterogeneity and minor evidence of publication bias, thus the association effect was included with and without these articles. The overall GRADE quality of evidence ranged from moderate to very high and highlighted five studies with a high level of imprecision. Conclusion: The lingering high prevalence of BQ in the Southeast Asia and Pacific regions, as well as its rising acceptance among non-ethnic Australians, is alarming and requires prompt and rigorous intervention to prevent the risk of oral cancer. Systematic Review Registration: PROSPERO (CRD42023429694).
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