Evidence map›Paper›PMID 38846074›Full record

ReviewRSC chemical biology2024

Recent advances in chemical biology tools for protein and RNA profiling of extracellular vesicles.

Woojeong Lim, Soyeon Lee, Minseob Koh, Ala Jo, Jongmin Park

Abstract readReview
In one paragraph

Review in RSC chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Woojeong LimDepartment of Chemistry, Kangwon National University Chuncheon 24341 Korea jpark@kangwon.ac.kr.
Soyeon LeeDepartment of Chemistry, Kangwon National University Chuncheon 24341 Korea jpark@kangwon.ac.kr.
Minseob KohDepartment of Chemistry, Pusan National University Busan 46241 Republic of Korea mikoh@pusan.ac.kr.ORCID https://orcid.org/0000-0003-1935-4776
Ala JoCenter for Nanomedicine, Institute for Basic Science Seoul 03722 Republic of Korea chemko88@gmail.com.
Jongmin ParkDepartment of Chemistry, Kangwon National University Chuncheon 24341 Korea jpark@kangwon.ac.kr.ORCID https://orcid.org/0000-0001-8338-9346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are nano-sized vesicles secreted by cells that contain various cellular components such as proteins, nucleic acids, and lipids from the parent cell. EVs are abundant in body fluids and can serve as circulating biomarkers for a variety of diseases or as a regulator of various biological processes. Considering these characteristics of EVs, analysis of the EV cargo has been spotlighted for disease diagnosis or to understand biological processes in biomedical research. Over the past decade, technologies for rapid and sensitive analysis of EVs in biofluids have evolved, but detection and isolation of targeted EVs in complex body fluids is still challenging due to the unique physical and biological properties of EVs. Recent advances in chemical biology provide new opportunities for efficient profiling of the molecular contents of EVs. A myriad of chemical biology tools have been harnessed to enhance the analytical performance of conventional assays for better understanding of EV biology. In this review, we will discuss the improvements that have been achieved using chemical biology tools.

Identifiers

PMID38846074
PMCPMC11151817

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.