Evidence map›Paper›PMID 38846021›Full record

ArticleGynecologic oncology reports2024

Preliminary results of adjuvant image-guided vaginal brachytherapy alone for early stage endometrial carcinoma.

Pooriwat Muangwong, Ekkasit Tharavichitkul, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Bongkot Jia-Mahasap, Piyapasara Toapichattrakul, Wannapha Nobnop, Anirut Watcharawipha, Razvan M Galalae and 1 more

Abstract read
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In one paragraph

Article in Gynecologic oncology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pooriwat MuangwongDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Ekkasit TharavichitkulDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Somvilai ChakrabandhuDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Pitchayaponne KlunklinDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Wimrak OnchanDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Bongkot Jia-MahasapDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Piyapasara ToapichattrakulDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Wannapha NobnopDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Anirut WatcharawiphaDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Razvan M GalalaeFaculty of Medicine, Christian-Albrechts-University, Kiel, Germany.
Imjai ChitapanaruxDivision of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This retrospective study evaluated the preliminary outcomes of image-guided vaginal brachytherapy (IG-VBT) in the adjuvant treatment of high intermediate risk endometrial cancer. Materials and Methods: Data were collected from 48 patients who underwent adjuvant IG-VBT between 2019 and 2022 at the Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University. The vaginal cuff clinical target volume (CTV-VC) is composed of a 4-mm-thick band around vaginal cylinder at the upper 3 cm of the vaginal cuff. A total dose of 21 Gy in three fractions was delivered to the CTV-VC, and the dose to the bladder and rectum were evaluated. Treatment details, patient characteristics, and outcomes were analyzed. Descriptive statistics were used for analysis, and Kaplan-Meier method was employed for survival analysis. Results: The mean age was 62 years, with mainly endometrioid carcinoma pathology (96 %). All patients were at stage I, with 87.5 % receiving complete surgical staging. Mean total treatment time was 10 days with mean D90 of CTV-VC was 29.7 Gy, and D2cc of bladder, rectum, and sigmoid were 24.6 Gy, 21.0 Gy, and 7.7 Gy, respectively. At a median follow-up of 37 months, 3-year local control, disease-free survival, and overall survival rates were 100 %, 100 %, and 97.9 %. respectively. Two patients (4.2 %) experienced grade 1-2 gastrointestinal toxicity, while no genitourinary toxicity or serious adverse events were observed. Conclusions: The preliminary results of IG-VBT in endometrial cancer demonstrated favorable outcomes in terms of vaginal control and toxicity. Further studies with larger cohorts and longer follow-up durations are warranted.

Indexed as

Early stageEndometrial carcinomaHigh intermediate riskImage-guided vaginal brachytherapy

Identifiers

PMID38846021
PMCPMC11153898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.