Evidence map›Paper›PMID 38846003›Full record

ArticleiScience2024

Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.

Taolin Yuan, Surinder Kumar, Mary E Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J Kunkel, Yanghan Liu, Elyse M Petrunak and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Taolin YuanHuman and Animal Physiology, Wageningen University, De Elst 1, Wageningen, the Netherlands.
Surinder KumarDepartment of Pathology & Laboratory Medicine, Miller School of Medicine, and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Mary E SkinnerDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Ryan Victor-JosephDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Majd AbuaitaDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Jaap KeijerHuman and Animal Physiology, Wageningen University, De Elst 1, Wageningen, the Netherlands.
Jessica ZhangDepartment of Pathology & Laboratory Medicine, Miller School of Medicine, and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Thaddeus J KunkelDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Yanghan LiuDepartment of Medicinal Chemistry, College of Pharmacy and Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Elyse M PetrunakLife Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Thomas L SaundersDivision of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Andrew P LiebermanDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Jeanne A StuckeyLife Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Nouri NeamatiDepartment of Medicinal Chemistry, College of Pharmacy and Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Fathiya Al-MurshediGenetic and Developmental Medicine Clinic, Department of Genetics, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman.
Majid AlfadhelMedical Genomic Research Department, King Abdullah International Medical Research Center(KAIMRC), King Saud Bin Abdulaziz University for Health Sciences(KSAU-HS), Ministry of National Guard Health Affairs (MNG-HA), Riyadh, Saudi Arabia.
Johannes N SpelbrinkRadboud Center for Mitochondrial Medicine, Department of Pediatrics, Radboud University Medical Center, Nijmegen, the Netherlands.
Richard RodenburgRadboud Center for Mitochondrial Medicine, Department of Pediatrics, Radboud University Medical Center, Nijmegen, the Netherlands.
Vincent C J de BoerHuman and Animal Physiology, Wageningen University, De Elst 1, Wageningen, the Netherlands.
David B LombardDepartment of Pathology & Laboratory Medicine, Miller School of Medicine, and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.

Funding

Regulation of one carbon metabolism and epigenetics by SIRT5R01GM101171 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOMBARD, DAVID BENNER · 2012 to 2021
$2.6M
NIGMS NIH HHS R01 GM101171
6 · The paper itself

Abstract

SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the phenotypes of SIRT5 deficiency are quite subtle. Here, we identify two homozygous

Indexed as

biochemistryhealth sciencesmolecular biologyneurosciencephysiologystructural biology

Identifiers

PMID38846003
PMCPMC11154205

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.