Evidence map›Paper›PMID 38845787›Full record

ArticleRespiratory medicine case reports2024

A case of autoimmune pulmonary alveolar proteinosis responding to oral statin therapy.

So Shimamura, Honami Morikawa, Ken Shinohara, Hiroki Ohkoshi, Chisa Omori, Yuuki Hoshino, Yoshinori Uchida, Saiki Masafumi, Shinnosuke Ikemura, Naoki Ohishi and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

So ShimamuraDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Honami MorikawaDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Ken ShinoharaDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Hiroki OhkoshiDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Chisa OmoriDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Yuuki HoshinoDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Yoshinori UchidaDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Saiki MasafumiDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Shinnosuke IkemuraDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Naoki OhishiDepartment of Pathology, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Tetsuo KondoDepartment of Pathology, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.
Kenzo SoejimaDepartment of Respiratory Medicine, Graduate School of Medicine University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3892, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is no approved drug treatment for autoimmune pulmonary alveolar proteinosis (APAP), although traditionally requires complex treatments such as whole lung lavage (WLL). We herein report on a 67-year-old man diagnosed with APAP. Treatment with atorvastatin (5 mg daily) resulted in significant improvement in symptoms, lung function, and computed tomography findings, with enhanced oxygenation, although serum anti-GM-CSF antibody levels remained elevated. This case suggests that the remission observed in this case could potentially be attributed to a direct effect of atorvastatin within the pulmonary alveoli. Statins may be considered as one of the treatment options for APAP.

Identifiers

PMID38845787
PMCPMC11154001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.