ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026
Systematic Review and Meta-analysis of the Association Between Mycoplasma genitalium and Pelvic Inflammatory Disease (PID).
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Comparative Epidemiology and Co-Detection ofPathogens (Basel, Switzerland) · 2026Article
- Clinical Manifestations and Associated Disease States withOpen forum infectious diseases · 2026Article
- The Role of Antimicrobial Susceptibility and Resistance Testing forOpen forum infectious diseases · 2026Article
- Trends and Themes inOpen forum infectious diseases · 2026Article
- Epidemiology and Molecular Characterization of Mycoplasmosis in Northeastern Part of Italy, 2023.Pathogens (Basel, Switzerland) · 2026Article
- PreconceptionmedRxiv : the preprint server for health sciences · 2026Article
- Cost of illness of Mycoplasma genitalium in Australia: an incidence-based approach incorporating resistance-guided therapy.Scientific reports · 2026Article
- Global, Regional, and National Impact of Pelvic Inflammatory Disease: Changing Landscape from 1990 to 2021.International journal of women's health · 2026Article
- Limited Role ofObstetrics and gynecology international · 2026Article
- Association of Smoking and Alcohol Consumption with Female Reproductive Diseases: A Mendelian Randomization Study on the Mediating Role of Circulating Metabolites.International journal of women's health · 2026Article
- Novel features ofMicrobial genomics · 2026Article
- Cervicovaginal microbiome composition and absolute quantity are associated with pelvic inflammatory disease.Microbial genomics · 2025Article
- In vitro evolution provides insights into mechanisms of Mycoplasma genitalium resistance to moxifloxacin.The Journal of antimicrobial chemotherapy · 2025Article
- Factors that contribute to the success of primary isolation ofJournal of medical microbiology · 2025Article
- A novel azithromycin resistance mutation in Mycoplasma genitalium induced in vitro.The Journal of antimicrobial chemotherapy · 2025Article
- The wartime prevalence of HIV, HBV, and reported STI-related syndromes among tested individuals in Ayder Comprehensive Specialized Hospital, Tigray, Ethiopia.BMC infectious diseases · 2025Article
- Prevalence and epidemiology ofFrontiers in public health · 2025Article
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7 authors.
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Abstract
backgroundDifferences in opinion concerning the contribution of Mycoplasma genitalium to pelvic inflammatory disease (PID) has resulted in inconsistencies across global testing and treatment guidelines. We conducted a systematic review and meta-analysis to determine the association between M. genitalium and PID and M. genitalium positivity within PID cases to provide a contemporary evidence base to inform clinical practice (PROSPERO registration: CRD42022382156).
methodsPubMed, Embase, Medline, and Web of Science were searched to 1 December 2023 for studies that assessed women for PID using established clinical criteria and used nucleic acid amplification tests to detect M. genitalium. We calculated summary estimates of the (1) association of M. genitalium with PID (pooled odds ratio [OR]) and 2) proportion of PID cases with M. genitalium detected (pooled M. genitalium positivity in PID), using random-effects meta-analyses, with 95% confidence intervals (CI).
resultsNineteen studies were included: 10 estimated M. genitalium association with PID, and 19 estimated M. genitalium positivity in PID. M. genitalium infection was significantly associated with PID (pooled OR = 1.67 [95% CI: 1.24-2.24]). The pooled positivity of M. genitalium in PID was 10.3% [95% CI: 5.63-15.99]. Subgroup and meta-regression analyses showed that M. genitalium positivity in PID was highest in the Americas, in studies conducted in both inpatient and outpatient clinic settings, and in populations at high risk of sexually transmitted infections.
conclusionsM. genitalium was associated with a 67% increase in odds of PID and was detected in about 1 of 10 clinical diagnoses of PID. These data support testing women for M. genitalium at initial PID diagnosis.
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