ArticleCancer medicine2024
Association between anxiety, depression, and symptom burden in patients with advanced colorectal cancer: A multicenter cross-sectional study.
Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Health-Related Quality of Life Among Patients With Ostomy Intestinal Stoma According to Sex and Ostomy Permanence: A Systematic Review and Meta-Analysis.International wound journal · 2026Pooled it
- Effects of Remote Web-Based Interventions on the Physiological and Psychological States of Patients With Cancer: Systematic Review With Meta-Analysis.JMIR mHealth and uHealth · 2025Pooled it
- Weight management in obese cancer patients during curative active treatment: protocol for the CANOBESE feasibility study.Pilot and feasibility studies · 2026Article
- Incongruent symptom perceptions and its associations with negative mood, intimate relationship and quality of life in colorectal cancer dyads: a dyadic analysis.Journal of patient-reported outcomes · 2026Article
- The relationship between perceived stress and depression in colorectal cancer patients: the mediating role of illness perception and the moderating role of self-efficacy.Frontiers in oncology · 2026Article
- Symptom network in patients with colorectal cancer during the perioperative period.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Trajectories and predictors of benefit finding among patients with colorectal cancer undergoing chemotherapy: A longitudinal observational study.Asia-Pacific journal of oncology nursing · 2025Article
- Association between anxiety, depression, and symptom burden in patients with advanced colorectal cancer: A multicenter cross-sectional study.Cancer medicine · 2024Article
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Authors and funding
22 authors.
Funding
Abstract
objectivesPatients with advanced colorectal cancer (CRC) have multiple concurrent physical and psychological symptoms. This study aimed to explore the relationship between anxiety, depression, and symptom burden in advanced CRC.
methodsA multicenter cross-sectional study was conducted in 10 cancer centers from geographically and economically diverse sites in China. A total of 454 patients with advanced CRC completed the Hospital Anxiety and Depression Scale and the MD Anderson Symptom Inventory. Multiple regression analysis was applied to explore the relationship between anxiety, depression and symptom burden.
resultsAbout one-third of the patients showed symptoms of anxiety or depression. Patients with anxiety or depression reported significantly higher symptom burden than those without (p < 0.001). Patients with anxiety or depression reported a higher proportion of moderate-to-severe (MS) symptom number than those without (p < 0.001). About 52% of the patients with anxiety or depression reported at least three MS symptoms. The prevalence of MS symptoms was ranging from 7.3% (shortness of breath) to 22% (disturbed sleep), and in patients with anxiety or depression was 2-10 times higher than in those without (p < 0.001). Disease stage (β = -2.55, p = 0.003), anxiety (β = 15.33, p < 0.001), and depression (β = 13.63, p < 0.001) were associated with higher symptom burden.
conclusionsAnxiety and depression in patients with advanced cancer correlated with higher symptom burden. Findings may lead oncology professionals to pay more attention to unrecognized and untreated psychological symptoms in symptom management for advanced cancer patients.
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