ArticleEuropean heart journal2024
Loop diuretic therapy with or without heart failure: impact on prognosis.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed.
- Impact of Loop Diuretics on Long-Term Kidney Outcome: A Post Hoc Analysis of the STOP-Angiotensin-Converting Enzyme Inhibitor Trial.Kidney360 · 2026Trial
- Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model.European heart journal · 2026Article
- Landmark clinical trials shaping contemporary guideline-directed medical therapy for heart failure.ESC heart failure · 2026Review
- Implications of Potential Undiagnosed HFpEF on Symptomatic Response With Coronary Revascularization.JACC. Heart failure · 2026Article
- Congestion and renal function in patients with chronic heart failure.ESC heart failure · 2026Article
- Association Between Reduction in Loop Diuretics and Heart Failure Rehospitalization After Transcatheter Aortic Valve Replacement.Circulation reports · 2026Article
- Temporal trends in the burden of heart failure in childbearing females aged 15-49 years globally from 1990 to 2021 and predictions for 2021-2050.European journal of medical research · 2025Article
- Health inequalities and trends in heart failure diagnosis in primary care in England, 2000-21: a national retrospective cohort data-linkage study.The Lancet. Primary care · 2025Article
- Loop Diuretic Therapy in Severe Aortic Stenosis: Marker of Organ Congestion, Unfavorable Hemodynamics, and Increased Post-Valve Replacement Mortality.Clinical cardiology · 2025Article
- Association Between Insulin Therapy and In-Hospital Death in Chronic Heart Failure Patients With Type 2 Diabetes Mellitus: Mediated by Plasma Volume.Journal of diabetes · 2025Article
- Developing core indicators for identifying people at risk of delayed heart failure diagnosis.BMC primary care · 2025Article
- Cardiologist follow-up and improved outcomes of heart failure: a French nationwide cohort.European heart journal · 2025Article
- Serial assessment of left ventricular ejection fraction for the management of heart failure: Unnecessary and unrealistic?European journal of heart failure · 2025Article
- Targeting Sodium in Heart Failure.Journal of personalized medicine · 2024Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND AND
aimsMany patients are prescribed loop diuretics without a diagnostic record of heart failure. Little is known about their characteristics and prognosis.
methodsGlasgow regional health records (2009-16) were obtained for adults with cardiovascular disease or taking loop diuretics. Outcomes were investigated using Cox models with hazard ratios adjusted for age, sex, socioeconomic deprivation, and comorbid disease (adjHR).
resultsOf 198 898 patients (median age 65 years; 55% women), 161 935 (81%) neither took loop diuretics nor had a diagnostic record of heart failure (reference group), 23 963 (12%) were taking loop diuretics but had no heart failure recorded, 7844 (4%) had heart failure recorded and took loop diuretics, and 5156 (3%) had heart failure recorded but were not receiving loop diuretics. Compared to the reference group, five-year mortality was only slightly higher for heart failure in the absence of loop diuretics [22%; adjHR 1.2 (95% CI 1.1-1.3)], substantially higher for those taking loop diuretics with no record of heart failure [40%; adjHR 1.8 (95% CI 1.7-1.8)], and highest for heart failure treated with loop diuretics [52%; adjHR 2.2 (95% CI 2.0-2.2)].
conclusionsFor patients with cardiovascular disease, many are prescribed loop diuretics without a recorded diagnosis of heart failure. Mortality is more strongly associated with loop diuretic use than with a record of heart failure. The diagnosis of heart failure may be often missed, or loop diuretic use is associated with other conditions with a prognosis similar to heart failure, or inappropriate loop diuretic use increases mortality; all might be true.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.