ArticleHGG advances2024
Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer.
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Article in HGG advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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Who cites it
4 citing papers in PubMed.
- The relationship between proactive health literacy and lifestyle behaviors among residents in a region of China.Frontiers in public health · 2026Article
- Co-expression-wide association studies link genetically regulated interactions with complex traits.Nature communications · 2025Article
- TransferTWAS: A transfer learning framework for cross-tissue transcriptome-wide association study.American journal of human genetics · 2025Article
- scTWAS Atlas: an integrative knowledgebase of single-cell transcriptome-wide association studies.Nucleic acids research · 2025Article
Corrections and comments
- Update of
Authors and funding
24 authors.
Dorothy M ChenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
Ruocheng DongDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA 94305, USA.
Linda KachuriDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA 94305, USA; Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA.
Thomas J HoffmannDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA.
Yu JiangDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20814, USA.
John P ShelleyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kerry R SchafferDepartment of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20814, USA.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20814, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20814, USA.
Shengchao A LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20814, USA.
Hans LiljaDepartments of Pathology and Laboratory Medicine, Surgery, Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Translational Medicine, Lund University, 21428 Malmö, Sweden.
Amy C JusticeArgonne National Laboratory, Lemont, IL 60439, USA.
Ravi K MadduriArgonne National Laboratory, Lemont, IL 60439, USA.
Alex A RodriguezArgonne National Laboratory, Lemont, IL 60439, USA.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20814, USA.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Population and Preventive Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
David V ContiCenter for Genetic Epidemiology, Department of Population and Preventive Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Robert J KleinDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jonathan D MosleyDepartments of Internal Medicine and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
John S WitteDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Epidemiology and Population Health, Stanford University, Stanford, CA 94305, USA; Departments of Biomedical Data Science and Genetics (by courtesy), Stanford University, Stanford, CA 94305, USA. Electronic address: jswitte@stanford.edu.
Rebecca E GraffDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: rebecca.graff@ucsf.edu.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MConduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MVanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9MModeling to Improve Prostate Cancer Outcomes Across Diverse PopulationsU01CA199338 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DE KONING, HARRY J, ETZIONI, RUTH D · 2015 to 2019
$5.2MMedical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8MGenetic Predictors of Prostate Cancer SurvivalR01CA244948 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROBERT J. KLEIN · 2021 to 2026
$4.1MPrecision Prostate Cancer Screening with Genetically Adjusted Prostate-Specific Antigen LevelsR01CA241410 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John S. Witte · 2020 to 2026
$3.7MImproving prostate cancer screening by integration of SNPs with blood biomarkersR01CA175491 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KLEIN, ROBERT J. · 2013 to 2018
$2.8MCOVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MComprehensive Investigation of Multiple Myeloma Genetic Susceptibility in African AmericansR00CA246076 · NCI · STANFORD UNIVERSITY · PI KACHURI, MIRLINDA · 2022 to 2024
$747kNCATS NIH HHS UL1 TR004419NCI NIH HHS K12 CA090625NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA246076NCI NIH HHS R01 CA175491NCI NIH HHS R01 CA241410NCI NIH HHS R01 CA244948NCI NIH HHS U01 CA199338NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284NIH HHS S10 OD026880NIH HHS S10 OD030463
Abstract
Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility for prostate cancer (PCa) screening. Using genome-wide association study (GWAS) summary statistics from 95,768 PCa-free men, we conducted a transcriptome-wide association study (TWAS) to examine impacts of genetically predicted gene expression on PSA. Analyses identified 41 statistically significant (p < 0.05/12,192 = 4.10 × 10
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyProstate-Specific AntigenProstatic NeoplasmsTranscriptomeGene Expression ProfilingHumansMalePolymorphism, Single NucleotideProstate-Specific Antigengene expressiongeneticsprostate cancerprostate-specific antigenscreeningtranscriptome-wide association study
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.