ArticleJournal of cachexia, sarcopenia and muscle2024
Total magnesium intake and risk of frailty in older women.
Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Diuretics in Cardiovascular Disease: For How Long and at What Dose?Journal of cardiovascular development and disease · 2026Review
- Magnesium as a Bioenergetic Checkpoint Linking Mitochondrial Function, Metabolic Disease, and Aging.Aging cell · 2026Review
- What Do We Know About Prevention of Frailty in Women?American journal of lifestyle medicine · 2025Review
- The impact of undernutrition on the association between hypomagnesemia and dynapenia in older women.BMC geriatrics · 2025Article
- Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.Scientific reports · 2025Article
- Comment on 'Total Magnesium Intake and Risk of Frailty in Older Women' by Struijk Et Al.Journal of cachexia, sarcopenia and muscle · 2024Article
- Total magnesium intake and risk of frailty in older women.Journal of cachexia, sarcopenia and muscle · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAn adequate magnesium intake might lower the risk of frailty through its role in muscle function.
methodsWe analysed data from 81 524 women aged ≥60 years participating in the Nurses' Health Study. Total magnesium intake was obtained from repeated food frequency questionnaires administered between 1984 and 2010 and self-reported information on supplementation. Frailty was defined as having at least three of the following five FRAIL scale criteria: fatigue, low strength, reduced aerobic capacity, having ≥5 chronic illnesses and weight loss ≥ 5%. The occurrence of frailty was assessed every 4 years from 1992 to 2018. Cox proportional hazards models adjusted for lifestyle factors, medication use and dietary factors were used to assess the association between magnesium intake and frailty.
resultsDuring a median follow-up of 16 years, we identified 15 477 incident cases of frailty. Women with a higher intake of total energy-adjusted magnesium had a decreased risk of frailty after adjustment for lifestyle factors, medication use and dietary factors. The relative risk (95% confidence interval) for Quintile 5 (Q5) versus Quintile 1 (Q1) was 0.88 (0.82, 0.94) (P-trend < 0.001). When only energy-adjusted magnesium from the diet was considered, the inverse association was stronger (Q5 vs. Q1: 0.68 [0.56, 0.82]; P-trend < 0.001). Those reaching the recommended daily allowance (RDA) of magnesium through diet had a 14% (9%, 19%) lower risk of frailty compared with those not meeting the RDA.
conclusionsIncreased intake of foods rich in magnesium was associated with a decreased risk of frailty.
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