Evidence map›Paper›PMID 38845100›Full record

ArticleJournal of occupational and environmental medicine2024

Maternal Exposure to Heavy Metals From Industrial Sources During Pregnancy and Childhood Cancer Risk in California.

Yixin Chen, Darcy Van Deventer, Roch Nianogo, Marco Vinceti, Wei Kang, Myles Cockburn, Noah Federman, Julia E Heck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of occupational and environmental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Air Pollution and Brain Tumors in Children. A Systematic Review.Current environmental health reports · 2026
    Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yixin ChenFrom the Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA (Y.C., D.V.D., R.N., J.E.H.); California Center for Population Research, University of California, Los Angeles, Los Angeles, CA (R.N.); CREAGEN-Environmental, Genetic, and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy (M.V.); Department of Epidemiology, School of Public Health, Boston University, Boston, MA (M.V.); Department of Geography and the Environment, University of North Texas, Denton, TX (W.K.); Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA (M.C.); Department of Pediatrics, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA (N.F.); and College of Health and Public Service, University of North Texas, Denton, TX (J.E.H.).ORCID 0000-0002-1545-9004
Darcy Van Deventer
Roch Nianogo
Marco Vinceti
Wei Kang
Myles Cockburn
Noah Federman
Julia E Heck

Funding

UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
Air Pollution and Childhood Cancers in CaliforniaR21ES018960 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2010 to 2011
$421k
Pesticide Exposure and Childhood Cancer StudyR21ES019986 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2011 to 2012
$409k
Childhood Cancer and Industrial Pollution (CHIP)R03CA252684 · NCI · UNIVERSITY OF NORTH TEXAS · PI HECK, JULIA · 2020 to 2020
$150k
NCI NIH HHS R03 CA252684NCI NIH HHS T32 CA009142NIEHS NIH HHS R21 ES018960NIEHS NIH HHS R21 ES019986
6 · The paper itself

Abstract

objectiveThe study investigated maternal exposure to heavy metals from industrial sources during pregnancy as potential risk factors for childhood cancer.

methodsCases ages 0-19 were identified from California Cancer Registry. Controls (20:1 ratio) were randomly selected from California Birth Registry, frequency-matched by birth year (1998-2016). We estimated maternal exposure to lead, nickel, and cobalt in ambient air from the Toxics Release Inventory. We examined "ever/never" and "high/low" exposures categorized by median exposure. Models were adjusted for maternal age, race/ethnicity, method of payment for prenatal care, neighborhood socioeconomic status, and urban/rural residence.

resultsAmong highly exposed persons, lead was associated with an increased teratoma risk (adjusted odds ratio [aOR]: 1.52; 95% confidence interval [CI]: 0.97, 2.37), whereas nickel was associated with an increased rhabdomyosarcoma risk (aOR: 1.45; 95% CI: 1.03, 2.04). Cobalt was associated with an increased glioma risk (aOR: 2.25; 95% CI: 1.39, 3.65) among ever-exposed persons. Inverse associations were found between Wilms tumor and nickel among the ever exposed and highly exposed (ever: aOR: 0.75; 95% CI: 0.59, 0.96; high: aOR: 0.64; 95% CI: 0.45, 0.93).

conclusionsFindings suggest that air pollution from heavy metals released by industrial sources may elevate childhood cancer risk.

Indexed as

Maternal ExposureMetals, HeavyNeoplasmsPrenatal Exposure Delayed EffectsAdolescentAdultCaliforniaCase-Control StudiesChildChild, PreschoolCobaltFemaleHumansIndustryInfantInfant, NewbornCobaltLeadMetals, HeavyNickel

Identifiers

PMID38845100
PMCPMC11371530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.