Evidence map›Paper›PMID 38844946›Full record

ArticleJournal of translational medicine2024

CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy.

Zihao Qi, Xiaojie Bai, Linjie Wu, Peng Zhang, Zhongqiang Guo, Ying Yu

Abstract read
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zihao QiDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China.
Xiaojie BaiDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China.
Linjie WuDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China.
Peng ZhangDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China. pzhang1988@whu.edu.cn.
Zhongqiang GuoDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China. guozhongqiang@whu.edu.cn.
Ying YuDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China. 00033705@whu.edu.cn.ORCID 0000-0003-3957-1460

Funding

Fundamental Research Funds for the Central Universities 2042022kf1136Natural Science Foundation of Hubei Province 2023AFB185
6 · The paper itself

Abstract

Apalutamide, a novel endocrine therapy agent, has been shown to significantly improve the prognosis of patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, resistance to apalutamide has also been reported, and the underlying mechanism for this response has yet to be clearly elucidated. First, this study established apalutamide-resistant prostate cancer (PCa) cells, and confirmed that apalutamide activated the release of calcium ions (Ca

Indexed as

AutophagyCalpainDrug Resistance, NeoplasmNeoplasm MetastasisProstatic NeoplasmsThiohydantoinsCalciumCell Line, TumorEndoplasmic Reticulum StressForkhead Box Protein O1Gene Expression Regulation, NeoplasticHumansMaleapalutamideCalciumCalpainCAPN2 protein, humanForkhead Box Protein O1ThiohydantoinsApalutamideAutophagyCalpain 2Forkhead Box O1Prostate cancer

Identifiers

PMID38844946
PMCPMC11155045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.