Evidence map›Paper›PMID 38844903›Full record

ArticleBMC ophthalmology2024

PRDX1 exerts a photoprotection effect by inhibiting oxidative stress and regulating MAPK signaling on retinal pigment epithelium.

Xiao-Ying Wen, Na Yang, Yang Gao, Wei-Na Ma, Yan Fu, Ren-Fei Geng, Yue-Ling Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. EarlyFrontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiao-Ying WenDepartment of Ophthalmology, Baoding NO.1 Central Hospital, Baoding, Hebei, China.
Na YangDepartment of Ophthalmology, Baoding NO.1 Central Hospital, Baoding, Hebei, China.
Yang GaoDepartment of Ophthalmology, Baoding NO.1 Central Hospital, Baoding, Hebei, China.
Wei-Na MaDepartment of Ophthalmology, Baoding NO.1 Central Hospital, Baoding, Hebei, China.
Yan FuDepartment of Ophthalmology, Baoding NO.1 Central Hospital, Baoding, Hebei, China.
Ren-Fei GengDepartment of Ophthalmology, Baoding NO.1 Central Hospital, Baoding, Hebei, China.
Yue-Ling ZhangDepartment of Ophthalmology, Baoding NO.1 Central Hospital, Baoding, Hebei, China. bdjfqlz@163.com.

Funding

Baoding Science and Technology Plan Project No.2141ZF263
6 · The paper itself

Abstract

backgroundThe purpose of this study was to investigate the photoprotection effect of peroxiredoxin 1 (PRDX1) protein in ultraviolet B (UVB) irradiation-induced damage of retinal pigment epithelium (RPE) and its possible molecular mechanism.

methodsARPE-19 cell viability and apoptosis were assessed by MTT assay and flow cytometry, respectively. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect the PRDX1 expression. The corresponding kits were employed to measure the levels or activities of lactate dehydrogenase (LDH), 8-hydroxy-2-deoxyguanosine (8-OHdG), reactive oxygen species (ROS), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD). Western blotting was applied to examine PRDX1 expression and mitogen-activated protein kinase (MAPK) signaling pathway-related proteins.

resultsAfter exposure to 20 mJ/cm

conclusionPRDX1 exerts a photoprotection effect on RPE by attenuating UVB-induced cell damage and inhibiting oxidative stress, which can be attributed to the inhibition of MAPK signaling pathway activation.

Indexed as

ApoptosisCell SurvivalOxidative StressPeroxiredoxinsReactive Oxygen SpeciesRetinal Pigment EpitheliumUltraviolet Rays8-Hydroxy-2'-DeoxyguanosineBlotting, WesternCell LineCells, CulturedHumansMAP Kinase Signaling SystemSignal Transduction8-Hydroxy-2'-DeoxyguanosinePeroxiredoxinsPRDX1 protein, humanReactive Oxygen SpeciesMitogen-activated protein kinase signaling pathwayPeroxiredoxin 1PhotoprotectionRetinal pigment epithelium

Identifiers

PMID38844903
PMCPMC11155104

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.