ArticleNature communications2024
Months-long tracking of neuronal ensembles spanning multiple brain areas with Ultra-Flexible Tentacle Electrodes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Noninvasive decoding of typed sentences from human brain activity.Nature neuroscience · 2026Article
- Repeatable, low-drift recordings in behaving nonhuman primates using flexible microelectrodes.Nature communications · 2026Article
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Umbrella-type stretchable electrode arrays for long-term neural recording.Nature communications · 2026Article
- A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.Cell reports methods · 2026Article
- E-Link: A 256-ch Mini-Pedestal Connector for High-Density Soft Neural Interfaces.IEEE journal on flexible electronics · 2026Article
- Magnetic resonance identification tags for ultra-flexible electrodes.Nature communications · 2026Article
- Friend, Not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Large-scale single-neuron recording in the human cortex using an ultra-flexible electrode array.Nature communications · 2026Article
- A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.bioRxiv : the preprint server for biology · 2026Article
- Benchmarking spike source localization algorithms in high density probes.PLoS computational biology · 2026Article
- Friend, not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.bioRxiv : the preprint server for biology · 2026Article
- Repeatable, low-drift recordings in behaving non-human primates using flexible microelectrodes.bioRxiv : the preprint server for biology · 2026Article
- Direct laser carbonization of parylene-C toward microelectrodes forFrontiers in neuroscience · 2026Article
- A method for efficient, rapid, and minimally invasive implantation of individual non-functional motes with penetrating subcellular-diameter carbon fiber electrodes into rat cortex.Frontiers in neuroscience · 2026Article
- Iris 128x: open-source 128 channel headstages for neural stimulation and recording.Journal of neural engineering · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Neural vs Neuromorphic Interfaces: Where Are We Standing?Chemical reviews · 2025Review
- Stiffness-Tunable Neurotentacles for Minimally Invasive Implantation and Long-Term Neural Activity Recordings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Flexible Depth Probes with PEDOT:PSS Microelectrodes for Chronic Recording and Stimulation.ACS applied materials & interfaces · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We introduce Ultra-Flexible Tentacle Electrodes (UFTEs), packing many independent fibers with the smallest possible footprint without limitation in recording depth using a combination of mechanical and chemical tethering for insertion. We demonstrate a scheme to implant UFTEs simultaneously into many brain areas at arbitrary locations without angle-of-insertion limitations, and a 512-channel wireless logger. Immunostaining reveals no detectable chronic tissue damage even after several months. Mean spike signal-to-noise ratios are 1.5-3x compared to the state-of-the-art, while the highest signal-to-noise ratios reach 89, and average cortical unit yields are ~1.75/channel. UFTEs can track the same neurons across sessions for at least 10 months (longest duration tested). We tracked inter- and intra-areal neuronal ensembles (neurons repeatedly co-activated within 25 ms) simultaneously from hippocampus, retrosplenial cortex, and medial prefrontal cortex in freely moving rodents. Average ensemble lifetimes were shorter than the durations over which we can track individual neurons. We identify two distinct classes of ensembles. Those tuned to sharp-wave ripples display the shortest lifetimes, and the ensemble members are mostly hippocampal. Yet, inter-areal ensembles with members from both hippocampus and cortex have weak tuning to sharp wave ripples, and some have unusual months-long lifetimes. Such inter-areal ensembles occasionally remain inactive for weeks before re-emerging.
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