ArticleProceedings of the National Academy of Sciences of the United States of America1979
Activation of mating type genes by transposition in Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Evolution of a Restriction Factor by Domestication of a Yeast Retrotransposon.Molecular biology and evolution · 2024Article
- Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023Review
- NADFrontiers in molecular biosciences · 2021Review
- Amar Klar: A giant among scientists (1947-2017).Journal of biosciences · 2017Article
- SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model.Neurochemical research · 2016Article
- A Unique DNA Recombination Mechanism of the Mating/Cell-type Switching of Fission Yeasts: a Review.Microbiology spectrum · 2014Review
- Sirtuins: from metabolic regulation to brain aging.Frontiers in aging neuroscience · 2013Article
- The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity.Handbook of experimental pharmacology · 2011Review
- The yeast mating-type switching mechanism: a memoir.Genetics · 2010Article
- The DNA end-binding protein Ku regulates silencing at the internal HML and HMR loci in Saccharomyces cerevisiae.Genetics · 2008Article
- Article
- Yeast mother cell-specific ageing, genetic (in)stability, and the somatic mutation theory of ageing.Nucleic acids research · 2007Review
- Conditional silencing: the HMRE mating-type silencer exerts a rapidly reversible position effect on the yeast HSP82 heat shock gene.Molecular and cellular biology · 1993Article
- Article
- The sum1-1 mutation affects silent mating-type gene transcription in Saccharomyces cerevisiae.Molecular and cellular biology · 1990Article
- The HML mating-type cassette of Saccharomyces cerevisiae is regulated by two separate but functionally equivalent silencers.Molecular and cellular biology · 1989Article
- Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae.Molecular and cellular biology · 1987Article
- Cloning and characterization of four SIR genes of Saccharomyces cerevisiae.Molecular and cellular biology · 1986Article
- Rearrangements of the transposable mating-type cassettes of fission yeast.The EMBO journal · 1984Article
- Recombination between antibody heavy chain variable-region genes: evidence for gene conversion.Proceedings of the National Academy of Sciences of the United States of America · 1983Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Yeast Saccharomyces cerevisiae may express an a or alpha mating type. These cells types may be interconverted as a consequence of heritable genetic alteractions at the mating type locus (MAT). According to the more general controlling element model [Oshima, U. & Takano, I. (1971) Genetics 67, 327--335] and the specific cassette model [Hicks, J., Strathern, J. & Herskowitz, I. (1977) in DNA Insertion Elements, Plasmids and Episomes, eds. Bukhari, A. I., Shapiro, J.A. & Adhya, S. L.(Cold Spring Harbor Laboratory, Cold Spring Harbor, NY), pp. 457--462], the regulatory information required for switching the MAT locus exists at two other loosely linked loci, HMa and HMalpha. Specifically, the HMa and HMalpha loci are proposed to carry silent alpha and silent a genes, respectively. According to these models, switching occurs when a replica of a silent gene replaces the resident information at the mating type locus and is thereby expressed. These models predict that mutations at the silent ("storage") loci would generate defective MAT loci subsequent to the switching process. Therefore, the behavior of HMalpha mutants during the mating type interconversion was investigated. The results demonstrate that defective MATa alleles are generated by switching the MATalpha locus in HMalpha mutants. Thus, the genetic information from HMalpha is transposed to the mating type locus. These results provide genetic evidence in support of these models.
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