Evidence map›Paper›PMID 38844451›Full record

ArticleNature communications2024

Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis.

Hongdong Wang, Yanhua Du, Shanshan Huang, Xitai Sun, Youqiong Ye, Haixiang Sun, Xuehui Chu, Xiaodong Shan, Yue Yuan, Lei Shen and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongdong Wang *Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Yanhua Du *Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanshan Huang *Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Xitai SunDepartment of General Surgery, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.
Youqiong YeShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-8332-4710
Haixiang SunDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Xuehui ChuDepartment of General Surgery, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.
Xiaodong ShanDepartment of General Surgery, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.
Yue YuanDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Lei ShenShanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lshen@shsmu.edu.cn.ORCID http://orcid.org/0000-0003-2811-7094
Yan BiDepartment of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China. biyan@nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose progenitor cells (APCs) are heterogeneous stromal cells and help to maintain metabolic homeostasis. However, the influence of obesity on human APC heterogeneity and the role of APC subpopulations on regulating glucose homeostasis remain unknown. Here, we find that APCs in human visceral adipose tissue contain four subsets. The composition and functionality of APCs are altered in patients with type 2 diabetes (T2D). CD9

Indexed as

Diabetes Mellitus, Type 2GlucoseHomeostasisObesitySingle-Cell AnalysisStem CellsAdipocytesAdipose TissueAnimalsFemaleHumansIntra-Abdominal FatLipolysisMaleMiceMice, Inbred C57BLGlucose

Identifiers

PMID38844451
PMCPMC11156882

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.