Evidence map›Paper›PMID 38843825›Full record

ArticleNature2024

Unlocking carbene reactivity by metallaphotoredox α-elimination.

Benjamin T Boyle, Nathan W Dow, Christopher B Kelly, Marian C Bryan, David W C MacMillan

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Iron-Catalyzed Cyclopropanation of Allenes Using Unactivated Alkyl Sulfonium Salts.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. C(spACS electrochemistry · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Rh-Catalyzed Enantioselective Aryl C-H Bond Cyclopropylation.Journal of the American Chemical Society · 2025
    Article
  16. Cyclopropanation with Non-Stabilized Carbenes via Ketyl Radicals.Journal of the American Chemical Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benjamin T Boyle *Merck Center for Catalysis, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-9360-2179
Nathan W Dow *Merck Center for Catalysis, Princeton University, Princeton, NJ, USA.
Christopher B KellyDiscovery Process Research, Janssen Research & Development, Spring House, PA, USA.
Marian C BryanTherapeutics Discovery, Janssen Research & Development, Spring House, PA, USA.ORCID 0000-0002-3138-6888
David W C MacMillanMerck Center for Catalysis, Princeton University, Princeton, NJ, USA. dmacmill@princeton.edu.ORCID 0000-0001-6447-0587

Funding

Photoredox Catalysis Applications in Organometallics and Chemical BiologyR35GM134897 · NIGMS · PRINCETON UNIVERSITY · PI David W MacMillan · 2020 to 2026
$6.3M
NIGMS NIH HHS R35 GM134897
6 · The paper itself

Abstract

The ability to tame high-energy intermediates is important for synthetic chemistry, enabling the construction of complex molecules and propelling advances in the field of synthesis. Along these lines, carbenes and carbenoid intermediates are particularly attractive, but often unknown, high-energy intermediates

Indexed as

AlcoholsAmino AcidsCarboxylic AcidsChemistry Techniques, SyntheticIronMethanePhotochemistryCarbonCatalysisCyclopropanesElectronsOxidation-ReductionAlcoholsAmino AcidscarbeneCarbonCarboxylic AcidscyclopropaneCyclopropanesIronMethane

Identifiers

PMID38843825
PMCPMC11481160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.