Evidence map›Paper›PMID 38843783›Full record

ArticleFetal diagnosis and therapy2024

A Novel Fetal Magnetic Resonance Imaging Lung Volume Nomogram Stratified by Estimated Fetal Weight.

Sivan Farladansky-Gershnabel, Praveen Jayapal, Max Zalcman, Richard A Barth, Erika Rubesova, Susan R Hintz, Jiaqi Zhang, Stephanie A Leonard, Yasser Y El-Sayed, Yair J Blumenfeld

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Article in Fetal diagnosis and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Sivan Farladansky-GershnabelDepartment of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel.
Praveen JayapalDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.
Max ZalcmanDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.
Richard A BarthDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.
Erika RubesovaDepartment of Radiology, Stanford University School of Medicine, Stanford, California, USA.
Susan R HintzDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Jiaqi ZhangDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.
Stephanie A LeonardDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.
Yasser Y El-SayedDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.
Yair J BlumenfeldDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.

Funding

Optimizing treatment of chronic hypertension in pregnancy using a national distributed data networkK01HL171699 · NHLBI · STANFORD UNIVERSITY · PI Stephanie A. Leonard · 2024 to 2026
$514k
NHLBI NIH HHS K01 HL171699
6 · The paper itself

Abstract

introductionFetal magnetic resonance imaging (MRI) lung volume nomograms are increasingly used to prognosticate neonatal outcomes in fetuses with suspected pulmonary hypoplasia. However, pregnancies complicated by fetal anomalies associated with pulmonary hypoplasia may also be complicated by fetal growth restriction (FGR). If a small lung volume is suspected in such cases, it is often unclear whether the lungs are "small" because of underlying lung pathology, or small fetal size. Existing MRI lung volume nomograms have mostly been stratified by gestational age (GA), rather than estimated fetal weight (EFW). Therefore, we aimed to develop a novel fetal lung volume nomogram stratified by EFW.

methodsConsecutive fetal MRIs performed at a quaternary medical center from 2019 to 2021 were analyzed. MRIs performed due to fetal lung anomalies and cases with FGR were excluded. All MRIs were performed without IV contrast on GE 3 or 1.5 Tesla scanners (GE Healthcare). Images were reviewed by three experienced fetal radiologists. Freehand ROI in square centimeter was drawn around the contours of the lungs on consecutive slices from the apex to the base. The volume of the right, left and total lungs were calculated in mL. Lung volumes were plotted by both EFW and GA.

resultsAmong 301 MRI studies performed during the study period, 170 cases met inclusion criteria and were analyzed. MRIs were performed between 19- and 38-week gestation, and a sonographic EFW was obtained within a mean of 2.9 days (SD ± 5.5 days, range 0-14 days) of each MRI. Nomograms stratified by both EFW and GA were created using 200 g. and weekly intervals respectively. A formula using EFW to predict total lung volume was calculated: LV = 0.07497804 EFW0.88276 (R2 = 0.87).

conclusionsWe developed a novel fetal lung volume nomogram stratified by EFW. If validated, this nomogram may assist clinicians predict outcomes in cases of fetal pulmonary hypoplasia with concomitant FGR.

Indexed as

Fetal WeightLungMagnetic Resonance ImagingNomogramsFemaleGestational AgeHumansLung Volume MeasurementsPregnancyPrenatal DiagnosisRetrospective StudiesEstimated fetal weightLung volumesMagnetic resonance imagingNomogram

Identifiers

PMID38843783
PMCPMC11475777

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