Evidence map›Paper›PMID 38843706›Full record

ArticleGait & posture2024

Cumulative loading increases and loading asymmetries persist during walking for people with a transfemoral bone-anchored limb.

Peter B Thomsen, Brecca M M Gaffney, James B Tracy, Nicholas W Vandenberg, Mohamed E Awad, Cory L Christiansen, Jason W Stoneback

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gait & posture, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peter B ThomsenUniversity of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Physical Medicine & Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; VA Eastern Colorado Healthcare System, Aurora, CO, USA. Electronic address: peter.thomsen@cuanschutz.edu.
Brecca M M GaffneyUniversity of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; VA Eastern Colorado Healthcare System, Aurora, CO, USA; Department of Mechanical Engineering, University of Colorado Denver, Denver, CO, USA; Center for Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
James B TracyUniversity of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Physical Medicine & Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; VA Eastern Colorado Healthcare System, Aurora, CO, USA.
Nicholas W VandenbergUniversity of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Mechanical Engineering, University of Colorado Denver, Denver, CO, USA.
Mohamed E AwadUniversity of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cory L ChristiansenUniversity of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Physical Medicine & Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; VA Eastern Colorado Healthcare System, Aurora, CO, USA.
Jason W StonebackUniversity of Colorado Bone-Anchored Limb Research Group, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Interdisciplinary Training in Musculoskeletal ResearchT32AR080630 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Karin A Payne, MICHAEL J ZUSCIK · 2022 to 2026
$1.7M
Effect of Osseointegrated Prostheses on the Pathogenesis of Hip Osteoarthritis in Patients with Lower Limb LossK01AR080776 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Brecca Gaffney · 2023 to 2026
$522k
Dynamic Bone-Implant Loading in Osseointegrated ProsthesesR03HD111012 · NICHD · UNIVERSITY OF COLORADO DENVER · PI GAFFNEY, BRECCA · 2023 to 2024
$289k
NCATS NIH HHS UL1 TR002535NIAMS NIH HHS K01 AR080776NIAMS NIH HHS T32 AR080630NICHD NIH HHS R03 HD111012
6 · The paper itself

Abstract

backgroundA bone-anchored limb (BAL) is an alternative to a traditional socket-type prosthesis for people with transfemoral amputation. Early laboratory-based evidence suggests improvement in joint and limb loading mechanics during walking with a BAL compared to socket prosthesis use. However, changes in cumulative joint and limb loading measures, which may be predictive of degenerative joint disease progression, remain unknown. RESEARCH QUESTION: Do cumulative total limb and hip joint loading during walking change using a BAL for people with unilateral transfemoral amputation, compared to prior socket prosthesis use?

methodsA case-series cohort of eight participants with prior unilateral transfemoral amputation who underwent BAL hardware implantation surgery were retrospectively analyzed (4 M/4 F; BMI: 27.7 ± 3.1 kg/m

resultsOne year after BAL hardware implantation, participants demonstrated bilateral increases in cumulative total limb loading (amputated: d = -0.65; intact: d = -0.72) and frontal-plane hip moment (amputated: d = -1.29; intact: d = -1.68). Total limb loading and hip joint loading in all planes remained asymmetric over time, with relative overloading of the intact limb in all variables of interest at the one-year point. SIGNIFICANCE: Despite increases in cumulative total limb and hip joint loading, between-limb loading asymmetries persist. Habitual loading asymmetry has been implicated in contributing to negative long-term joint health and onset or progression of degenerative joint diseases. Improved understanding of methods to address habitual loading asymmetries is needed to optimize rehabilitation and long-term joint health as people with transfemoral amputation increase physical activity when using a BAL.

Indexed as

Artificial LimbsWalkingAdultAmputation, SurgicalAmputeesBiomechanical PhenomenaBone-Anchored ProsthesisFemaleFemurHip JointHumansMaleMiddle AgedProsthesis DesignRetrospective StudiesWeight-BearingAmputationBone-anchored limbCumulative loadOsseointegrationTransfemoral

Identifiers

PMID38843706
PMCPMC11381168

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.