ArticlePLoS computational biology2024
Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression.
Article in PLoS computational biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Arousal state alters brain network switching and moderates cognitive task performance.bioRxiv : the preprint server for biology · 2026Article
- Effects of predicted Khamisiyah exposure on default mode network resting state functional connectivity in Gulf War Veterans.Frontiers in toxicology · 2026Article
- Intrinsic ion dynamics underlies the temporal nature of resting-state functional connectivity.bioRxiv : the preprint server for biology · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans,Neuroimage. Reports · 2024Article
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Authors and funding
7 authors.
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Abstract
Brain activity during the resting state is widely used to examine brain organization, cognition and alterations in disease states. While it is known that neuromodulation and the state of alertness impact resting-state activity, neural mechanisms behind such modulation of resting-state activity are unknown. In this work, we used a computational model to demonstrate that change in excitability and recurrent connections, due to cholinergic modulation, impacts resting-state activity. The results of such modulation in the model match closely with experimental work on direct cholinergic modulation of Default Mode Network (DMN) in rodents. We further extended our study to the human connectome derived from diffusion-weighted MRI. In human resting-state simulations, an increase in cholinergic input resulted in a brain-wide reduction of functional connectivity. Furthermore, selective cholinergic modulation of DMN closely captured experimentally observed transitions between the baseline resting state and states with suppressed DMN fluctuations associated with attention to external tasks. Our study thus provides insight into potential neural mechanisms for the effects of cholinergic neuromodulation on resting-state activity and its dynamics.
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