ArticlePloS one2024
Exploring the link: Systemic immune-inflammation index as a marker in endometriosis-Insights from the NHANES 2001-2006 cross-sectional study.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- A multicenter observational study of the association between systemic immune inflammation index and adenomyosis.iScience · 2026Article
- The inhibition of deep peritoneal endometriosis by Andrographolide through macrophage M1 activity in an endometriosis mice model.Veterinarni medicina · 2026Article
- Antioxidant dietary patterns mitigate pain and raise psychological wellbeing in ovarian endometrioma: surgical status shapes associations.Frontiers in nutrition · 2026Article
- Association between daily sitting time and accelerated aging in women: double mediation effects of systemic immune-inflammation index and creatinine.Aging clinical and experimental research · 2025Article
- Changes in the M1/M2 ratio due to andrographolide therapy for deep endometriosis: An experimental study using a BALB/C endometriosis model.Open veterinary journal · 2025Article
- Association Between Triglyceride-Glucose Related Index and Endometriosis Varies According to Educational Level.Nutrients · 2025Article
- Association between the C-reactive protein-triglyceride-glucose index and endometriosis: a cross-sectional study using data from the national health and nutrition examination survey, 1996-2006.BMC women's health · 2025Article
- Immunomodulatory insights of monoterpene glycosides in endometriosis: immune infiltration and target pathways analysis.Hereditas · 2025Article
- Impact of the lipid-inflammation axis on endometriosis risk: a multicenter case-control study using mediation analysis.Frontiers in endocrinology · 2025Article
- Relationship Between Inflammation-Nutrition Composite Indices and Ovarian Endometrioma: A Retrospective Observational Study.Journal of inflammation research · 2025Article
- Association Between the C-Reactive Protein-Albumin-Lymphocyte Index and Endometriosis: Insights from the 1999-2006 National Health and Nutrition Examination Survey.International journal of women's health · 2025Article
- Association between cardiometabolic Index (CMI) and endometriosis: a cross-sectional study on NHANES.Lipids in health and disease · 2024Article
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Abstract
objectiveThe systemic immuno-inflammatory index (SII), a novel immune marker of inflammation, has not been previously associated with endometriosis. The objective of this research is to explore the link between SII and the occurrence of endometriosis.
methodsUtilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2001 to 2006, we screened and extracted relevant information from the population. Participants missing data on either SII or endometriosis were excluded. We divided the remaining cohort into quartiles based on SII levels: Q1 (SII < 249, n = 848), Q2 (249 ≤ SII < 604.55, n = 847), Q3 (604.55 ≤ SII < 825.35, n = 847), and Q4 (SII ≥ 852.35, n = 848). Multiple linear regression and smooth curve fitting techniques, were to evaluate the non-linear association between SII and endometriosis.
resultsThe study included 3,390 adults aged 20 to 55. Multiple linear regression analysis revealed a significant positive correlation between SII and endometriosis [3.14, 95% CI (2.22, 4.45), P < 0.01]. This correlation was consistent across subgroups defined by marital status, poverty income ratio, BMI, alcohol consumption, and age at first menstrual period. However, the relationship between SII and endometriosis was significantly modified by age, education, and history of pregnancy in the stratified analyses. The curve fitting indicated an S-shaped curve, with an inflection point at SII = 1105.76.
conclusionThe SII may serve as a predictive marker for endometriosis risk among women in the United States, offering a potentially simple and cost-effective approach. However, given the cross-sectional design of this investigation, further validation in prospective studies is necessary.
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