ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2024
Proteomic profiling of human dental enamel affected by molar incisor hypomineralisation of different clinical severity grades: an in vitro study.
Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparative label-free quantitative proteomics of hypomineralised second primary molars (HSPM) and molar incisor hypomineralisation (MIH) reveals divergent enamel protein signatures underpinning distinct pathogenic mechanisms.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Proteomic Signatures of Dental Enamel Hypomineralization: Divergent Molecular Pathways in Coal-Burning vs. Drinking-Water Fluorosis.Biological trace element research · 2026Article
- Micro-Raman Spectroscopy Reveals Compositional Alterations in Molar Incisor Hypomineralization and Enamel Adjacent to Demarcated Opacities.Calcified tissue international · 2026Article
- A scoping review of proteomic alterations in molar-incisor hypomineralisation: insights from enamel and salivary composition.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeThe aim of this study was to explore the potential to profile and distinguish varying clinical severity grades of MIH, compared to normal enamel, using proteomics.
methodsLiquid chromatography-mass spectrometry analyses were conducted on enamel samples of extracted teeth, from 11 children and adolescents, spanning an age range of 6-18 years. Enamel powder samples were collected from extracted, third molars (n = 3) and first permanent molars diagnosed with MIH (n = 8). The MIH tooth samples were categorized into subgroups based on clinical severity grade. The data were statistically analyzed using ANOVA and Welch's t test.
resultsTeeth affected by MIH exhibited a diverse array of proteins, each with different functions related to dental enamel, distinguishing them from their normal enamel counterparts. The application of microdissection combined with LC-MS techniques has revealed the potential to discern unique proteomic profiles among MIH-affected teeth, characterized by varying clinical severity grades. Both analyzed MIH groups displayed consistent trends in the presentation of biological processes, including underabundance of proteins primarily associated with cell organization and biogenesis. Furthermore, proteins linked to cell death were overabundant in both MIH groups.
conclusionProteomics enabled the detection and differentiation of various proteins across different clinical severity grades of MIH.
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