Evidence map›Paper›PMID 38842690›Full record

ReviewSkeletal radiology2025

Erdheim-Chester disease and nuclear medicine imaging. A case report and brief review.

D Bountas, M Bountas, P Exadactylou, C Tziafalia, C Dimitriadis, A Doumas

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

D BountasIppokratis Nuclear Medicine Center, Thessaloniki, Greece. dibu@hotmail.gr.
M BountasAristotle University of Thessaloniki Medical School, Thessaloniki, Greece.ORCID http://orcid.org/0009-0001-4809-7193
P ExadactylouDpt of Nuclear Medicine, Aristotle University of Thessaloniki Medical School, AHEPA University Hospital, Thessaloniki, Greece.
C TziafaliaMedical Multidiagnostic Center, Euromedica Karditsa, Karditsa, Greece.
C DimitriadisInternal Medicine Private Practice, Karditsa, Greece.
A DoumasIppokratis Nuclear Medicine Center, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erdheim-Chester disease (ECD) is a rare clonal myeloid neoplasm typically affecting adults over 50 years old, with bone lesions in almost all patients. The prognosis is poor in most cases if left untreated. Clinical manifestations are not specific, which hinders early diagnosis. The disease has distinct radiological features. However, three-phase bone scintigraphy exhibits the most typical pattern of all imaging modalities, which is the prominent strikingly symmetrical radiotracer uptake in the distal ends of the femurs and proximal and distal ends of the tibiae, sparing the epiphyses. We report a case of a 54-year-old female patient, presenting with atypical persistent knee joint pain. After an MRI scan, she underwent a three-phase bone scan, revealing the characteristic pattern, thus indicating a possible ECD diagnosis, which was eventually confirmed in biopsy material. Novel aspects of the pathophysiology and treatment of the disease, as well as a differential diagnosis from the perspective of an MSK radiologist and nuclear medicine physician, are also discussed.

Indexed as

Erdheim-Chester DiseaseMagnetic Resonance ImagingRadiopharmaceuticalsBiopsyDiagnosis, DifferentialFemaleHumansMiddle AgedRadionuclide ImagingRadiopharmaceuticalsBone scintigraphyErdheim Chester diseaseNuclear medicine imaging

Identifiers

PMID38842690

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.