Evidence map›Paper›PMID 38842662›Full record

ArticleMetabolic brain disease2024

Inhibitor of apoptosis stimulating protein of p53 protects against MPP

Lei Chen, Fengju Duan, Fangfang Ge, Lu Tian, Yuanyuan Li, Ying Li, Qing Zhu, Qiong Zhou, Hong Lin

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lei ChenNeurosurgery, Xi'an International Medical Center Hospital, Xi'an, 710075, China.ORCID 0009-0004-8645-4528
Fengju DuanNeurology, Xi'an International Medical Center Hospital, No. 777 Xitai Road, Xi'an, 710075, China.ORCID 0009-0003-8440-3287
Fangfang GeNeurology, Xi'an International Medical Center Hospital, No. 777 Xitai Road, Xi'an, 710075, China.ORCID 0000-0001-6702-0127
Lu TianNeurology, Xi'an International Medical Center Hospital, No. 777 Xitai Road, Xi'an, 710075, China.ORCID 0009-0006-4508-123X
Yuanyuan LiNeurology, Xi'an International Medical Center Hospital, No. 777 Xitai Road, Xi'an, 710075, China.ORCID 0009-0007-1156-0969
Ying LiNeurology, Xi'an International Medical Center Hospital, No. 777 Xitai Road, Xi'an, 710075, China.ORCID 0009-0005-7469-8637
Qing ZhuNeurology, Xi'an International Medical Center Hospital, No. 777 Xitai Road, Xi'an, 710075, China.ORCID 0009-0000-2118-5647
Qiong ZhouNeurology, Xi'an International Medical Center Hospital, No. 777 Xitai Road, Xi'an, 710075, China. tangduzhouq@163.com.ORCID 0009-0002-5202-5958
Hong LinNeurology, Xi'an International Medical Center Hospital, No. 777 Xitai Road, Xi'an, 710075, China. hlin312@163.com.ORCID 0009-0002-1154-8867

Funding

Natural Science Basic Research Program of Shaanxi Province 107045689050
6 · The paper itself

Abstract

Inhibitor of apoptosis stimulating protein of p53 (iASPP) is related to the pathogenesis of several neurological disorders by affecting the oxidative stress and survival of neurons. However, whether iASPP has a role in Parkinson disease (PD) remains to be determined. This work explored the potential regulatory effect of iASPP in an in vitro model of PD based on 1-methyl-4-phenylpyridinium (MPP

Indexed as

1-Methyl-4-phenylpyridiniumDopaminergic NeuronsKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Parkinson DiseaseRepressor ProteinsAnimalsApoptosisMiceOxidative Stress1-Methyl-4-phenylpyridiniumKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2Repressor ProteinsApoptosisKeap1Nrf2Oxidative stressParkinson diseaseΑ-synuclein

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.