SynthesisRadiology. Cardiothoracic imaging2024
Effects of Enzyme Replacement Therapy on Cardiac MRI Findings in Fabry Disease: A Systematic Review and Meta-Analysis.
Abstract readSystematic ReviewMeta-Analysis
In one paragraph
Synthesis in Radiology. Cardiothoracic imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Imaging predictors of adverse prognosis in Fabry disease cardiomyopathy: A systematic review and meta-analysis.European journal of clinical investigation · 2025Pooled it
- A systematic literature review to evaluate the cardiac and cerebrovascular outcomes of patients with Fabry disease treated with agalsidase Beta.Frontiers in cardiovascular medicine · 2024Pooled it
- Fabry disease cardiomyopathy: A state-of-the-art review.Progress in cardiovascular diseasesPooled it
- A proteomic atlas phenotyping Fabry disease identifies a precise cardiovascular risk signature that integrates mitochondrial and lysosomal pathways.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Classification of cardiomyopathies: bringing order to complexity.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Early diagnosis of cardiac involvement in Anderson-Fabry disease using cardiac MRI parameters.Future cardiology · 2025Review
- Looking for Fabry, Finding More: LVH Screening Yields Unexpected Gaucher Diagnosis.Medical sciences (Basel, Switzerland) · 2025Article
- Progress and Challenges in the Treatment of Fabry Disease.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025Review
- Review
- Feasibility and Role of Cardiac Magnetic Resonance in Intensive and Acute Cardiovascular Care.Journal of clinical medicine · 2025Review
- Article
- Lysosomal storage diseases in North America: a comprehensive review of enzyme therapies and unmet needs.Therapeutic advances in rare diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Stefano Figliozzi *From the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0000-0003-2991-1548
Eleni Kollia *From the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0009-0005-4129-8872
Alexandros SimistirasFrom the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0000-0002-7683-7400
Antonia CamporealeFrom the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).
Kamil StankowskiFrom the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0000-0001-7088-8509
Pier Giorgio MasciFrom the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0000-0001-5196-9530
George MavraganisFrom the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0000-0002-7752-7949
Massimo LombardiFrom the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).
Gianluigi CondorelliFrom the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).
Marco FranconeFrom the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0000-0002-7906-3420
Maurizio Pieroni *From the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0000-0002-6830-4292
Georgios Georgiopoulos *From the Cardio Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Milan, Italy (S.F., G.C., M.F.); Emergency Department, Hippokrateio General Hospital of Athens, Athens, Greece (E.K.); Institute for Bioinnovation, BSRC Alexander Fleming, Vari, Greece (A.S.); Multimodality Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy (A.C., M.L., G.C., M.F.); Hunimed, Humanitas University, Pieve Emanuele, Milan, Italy (K.S.); King's College London, London, United Kingdom (P.G.M.); National and Kapodistrian University of Athens, Athens, Greece (G.M., G.G.); and San Donato Hospital, Arezzo, Italy (M.P.).ORCID 0000-0001-7661-5253
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose To perform a systematic review and meta-analysis to assess the effect of enzyme replacement therapy on cardiac MRI parameters in patients with Fabry disease. Materials and Methods A systematic literature search was conducted from January 1, 2000, through January 1, 2024, in PubMed, ClinicalTrials.gov, Embase, and Cochrane Library databases. Study outcomes were changes in the following parameters:
Indexed as
Enzyme Replacement TherapyFabry DiseaseMagnetic Resonance ImagingHeart VentriclesHumansCardiac MRIEnzyme Replacement Therapy (ERT)Fabry DiseaseLate Gadolinium Enhancement (LGE)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.