Evidence map›Paper›PMID 38842434›Full record

ArticlePhysical chemistry chemical physics : PCCP2024

Tracking protein-protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome

Alaina M Richard, D Fernando Estrada, Liam Flynn, Susan Sondej Pochapsky, Emily E Scott, Thomas C Pochapsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physical chemistry chemical physics : PCCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alaina M RichardChemical Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.ORCID http://orcid.org/0000-0002-2275-8176
D Fernando EstradaDepartment of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA.
Liam FlynnDepartment of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA. pochapsk@brandeis.edu.
Susan Sondej PochapskyDepartment of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA. pochapsk@brandeis.edu.
Emily E ScottChemical Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.ORCID http://orcid.org/0000-0002-5538-5716
Thomas C PochapskyDepartment of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA. pochapsk@brandeis.edu.ORCID http://orcid.org/0000-0001-8995-1088

Funding

TRAFFICKING OF THE PLASMA MEMBRANE CA2+-ATPASE TO RAFTSP20RR017708 · NCRR · UNIVERSITY OF KANSAS LAWRENCE · PI FISCHER, CHRISTOPHER JAMES · 2002 to 2011
$20.1M
Structural Basis of Cytochrome P450 ActivityR01GM076343 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI SCOTT, EMILY E · 2006 to 2014
$2.9M
Protein Structure and FunctionP20GM103420 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2012 to 2012
$2.0M
Structure and dynamics of clinically-relevant cytochrome P450 enzymes - Summer undergraduate research experience supplementR01GM130997 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POCHAPSKY, THOMAS CHARLES, SCOTT, EMILY E · 2019 to 2022
$1.8M
NCRR NIH HHS P20 RR017708NIGMS NIH HHS P20 GM103420NIGMS NIH HHS R01 GM076343NIGMS NIH HHS R01 GM130997
6 · The paper itself

Abstract

The human steroidogenic cytochrome P450 CYP17A1 catalyzes two types of reactions in the biosynthetic pathway leading from pregnenolone to testosterone and several other steroid hormones. The first is the hydroxylation of pregnenolone or progesterone to the corresponding 17α-hydroxy steroid, followed by a lyase reaction that converts these 17α-hydroxy intermediates to the androgens dehydroepiandrosterone and androstenedione, respectively. cytochrome

Indexed as

Cytochromes b5Steroid 17-alpha-HydroxylaseAndrostenesHumansMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularOxidation-ReductionProtein BindingProtein ConformationabirateroneAndrostenesCYP17A1 protein, humanCytochromes b5Steroid 17-alpha-Hydroxylase

Identifiers

PMID38842434
PMCPMC11186455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.