Evidence map›Paper›PMID 38842335›Full record

ArticleJournal of virology2024

Changes in the chikungunya virus E1 glycoprotein domain II and hinge influence E2 conformation, infectivity, and virus-receptor interactions.

Sara A Thannickal, Leandro Battini, Sophie N Spector, Maria G Noval, Diego E Álvarez, Kenneth A Stapleford

Abstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Glycosylation of GETV E2 promotes pathogenesis in animal models.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara A ThannickalDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-7028-3507
Leandro BattiniLaboratorio de Química Medicinal, Centro de Investigaciones en Bionanociencias (CIBON), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina.
Sophie N SpectorDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0001-9729-070X
Maria G NovalDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-9140-0565
Diego E ÁlvarezInstituto de Investigaciones Biotecnológicas, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de San Martín, San Martín, Argentina.ORCID 0000-0002-4449-9670
Kenneth A StaplefordDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-7796-2254

Funding

Mechanisms of alphavirus infectivity and adaptation - Resubmission - 1R01AI162774 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI Kenneth Stapleford · 2022 to 2026
$2.7M
UC San Diego RAPID Faculty Development Program in Infectious DiseasesR25AI147376 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADRIANA H TREMOULET, Joann Trejo · 2020 to 2026
$2.5M
NIAID NIH HHS R01 AI162774NIAID NIH HHS R25 AI147376
6 · The paper itself

Abstract

In a previous study to understand how the chikungunya virus (CHIKV) E1 glycoprotein β-strand c functions, we identified several attenuating variants at E1 residue V80 and the emergence of second-site mutations in the fusion loop (E1-M88L) and hinge region (E1-N20Y) with the V80 variants

Indexed as

Chikungunya FeverChikungunya virusViral Envelope ProteinsAnimalsCell LineHumansMiceMolecular Dynamics SimulationMutationProtein BindingProtein ConformationReceptors, VirusVirus InternalizationE1 envelope protein, Chikungunya virusReceptors, VirusViral Envelope Proteinsalphavirusdynamicsglycoproteininfectivitymammalmosquito

Identifiers

PMID38842335
PMCPMC11265345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.