Evidence map›Paper›PMID 38842325›Full record

ArticleAntimicrobial agents and chemotherapy2024

Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach.

Bhargavi Srija Ramisetty, Sihyung Yang, Thomas P C Dorlo, Michael Zhuo Wang

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. EXCLI journal · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bhargavi Srija RamisettyDepartment of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USA.ORCID 0009-0009-0140-115X
Sihyung YangDepartment of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USA.
Thomas P C DorloPharmacometrics Research Group, Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Michael Zhuo WangDepartment of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0003-2494-4172

Funding

Identification of CYP5122A1 inhibitors as chemical probes for Leishmania biologyR01AI139198 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI WANG, ZHUO MICHAEL · 2019 to 2022
$2.1M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI139198NIAID NIH HHS R01 AI139198
6 · The paper itself

Abstract

Miltefosine (MTS) is the only approved oral drug for treating leishmaniasis caused by intracellular

Indexed as

Antiprotozoal AgentsPhosphorylcholineAdministration, OralAnimalsFemaleHumansMaleMiceRatsTissue DistributionAntiprotozoal AgentsmiltefosinePhosphorylcholineinterspecies extrapolationleishmaniasismiltefosinepharmacometricsphysiologically-based pharmacokinetic modeling (PBPK)tissue distribution

Identifiers

PMID38842325
PMCPMC11232387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.