Evidence map›Paper›PMID 38842255›Full record

ArticleMolecular biology and evolution2024

Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds.

Shi-Zhi Wang, Yu Yan, Malin Widlund, Chen-Chang Qian, Liang-Liang Zhang, Shao-Jie Zhang, Zi-Mai Li, Peng Cao, Qing-Yan Dai, Xiao-Tian Feng and 8 more

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Article in Molecular biology and evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shi-Zhi WangKey Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Yu YanState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.
Malin WidlundDepartment of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
Chen-Chang QianKey Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Liang-Liang ZhangXingzhi College, Zhejiang Normal University, Jinhua, China.
Shao-Jie ZhangKey Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Zi-Mai LiState Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Peng CaoKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Qing-Yan DaiKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Xiao-Tian FengKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Feng LiuKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.
Lu WangState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China.
Chao GaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Qiao-Mei FuKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-7141-0002
Marjo K HytönenDepartment of Medical and Clinical Genetics, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Hannes LohiDepartment of Medical and Clinical Genetics, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Peter SavolainenDepartment of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
Guo-Dong WangKey Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.ORCID 0000-0002-9407-4363

Funding

National Key R&D Program of China 2019YFA0707101NSFC 32170436Yunnan Fundamental Research
6 · The paper itself

Abstract

The origins and extreme morphological evolution of the modern dog breeds are poorly studied because the founder populations are extinct. Here, we analyse eight 100 to 200 years old dog fur samples obtained from traditional North Swedish clothing, to explore the origin and artificial selection of the modern Nordic Lapphund and Elkhound dog breeds. Population genomic analysis confirmed the Lapphund and Elkhound breeds to originate from the local dog population, and showed a distinct decrease in genetic diversity in agreement with intense breeding. We identified eleven genes under positive selection during the breed development. In particular, the MSRB3 gene, associated with breed-related ear morphology, was selected in all Lapphund and Elkhound breeds, and functional assays showed that a SNP mutation in the 3'UTR region suppresses its expression through miRNA regulation. Our findings demonstrate analysis of near-modern dog artifacts as an effective tool for interpreting the origin and artificial selection of the modern dog breeds.

Indexed as

Animal FurSelection, GeneticAnimalsBreedingDogsGenetic VariationMicroRNAsPolymorphism, Single NucleotideSwedenMicroRNAsartificial selectionelkhoundgenetic originhistoric dog furlapphundpopulation genomics

Identifiers

PMID38842255
PMCPMC11226788

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.