Evidence map›Paper›PMID 38841895›Full record

ArticleGut microbes

Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of

Chih-Ming Chen, Chien-Chen Wu, Yebeen Kim, Wei-Yu Hsu, Ying-Chieh Tsai, Shu-Ling Chiu

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Isolation and genetic analysis of anBiochemistry and biophysics reports · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chih-Ming ChenInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chien-Chen WuResearch and Development Department, Bened Biomedical Co. Ltd, Taipei, Taiwan.
Yebeen KimInstitute of Cellular and Organismic Biology and Neuroscience Program of Academia Sinica, Academia Sinica, Taipei, Taiwan.
Wei-Yu HsuInstitute of Cellular and Organismic Biology and Neuroscience Program of Academia Sinica, Academia Sinica, Taipei, Taiwan.
Ying-Chieh TsaiInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Shu-Ling ChiuInstitute of Cellular and Organismic Biology and Neuroscience Program of Academia Sinica, Academia Sinica, Taipei, Taiwan.ORCID 0000-0003-4429-7830

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting over 1% of the global population. Individuals with ASD often exhibit complex behavioral conditions, including significant social difficulties and repetitive behaviors. Moreover, ASD often co-occurs with several other conditions, including intellectual disabilities and anxiety disorders. The etiology of ASD remains largely unknown owing to its complex genetic variations and associated environmental risks. Ultimately, this poses a fundamental challenge for the development of effective ASD treatment strategies. Previously, we demonstrated that daily supplementation with the probiotic

Indexed as

Autism Spectrum DisorderDisease Models, AnimalProbioticsSocial BehaviorAnimalsBehavior, AnimalFemaleGastrointestinal MicrobiomeHippocampusHumansLactiplantibacillus plantarumMaleMiceMice, Inbred C57BLOxytocinPrefrontal CortexOxytocinValproic AcidASD mouse modeldendritic arborizationGut microbiotahippocampusneuronal connectivityparaventricular nucleusvalproic acid

Identifiers

PMID38841895
PMCPMC11164232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.