ArticleAnnals of surgery2025
Infrapopliteal Endovascular Interventions for Claudication Are Associated With Poor Long-term Outcomes in Medicare-matched Registry Patients.
Article in Annals of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- A narrative review of imaging misallocation in peripheral artery disease: a value-based medicine perspective.Cardiovascular diagnosis and therapy · 2025Review
- When to Surgically Intervene for Claudication?Advances in surgery · 2025Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
objectiveTo evaluate the association of infrapopliteal peripheral vascular intervention (PVI) with long-term outcomes compared with isolated femoropopliteal PVI for the treatment of claudication.
backgroundThere are limited data supporting or opposing the use of infrapopliteal PVIs for the treatment of claudication.
methodsWe conducted a retrospective analysis of all patients in the Medicare-matched Vascular Quality Initiative database who underwent an index infrainguinal PVI for claudication from January 2004 to December 2019 using Cox proportional hazards models.
resultsOf 14,261 patients (39.9% females; 85.6% age ≥65 years, 87.7% non-Hispanic White) who underwent an index infrainguinal PVI for claudication, 16.6% (N = 2369) received an infrapopliteal PVI. The median follow-up after index PVI was 3.7 years (interquartile range: 2.1-6.1). Compared with patients who underwent isolated femoropopliteal PVI, patients receiving any infrapopliteal PVI had a higher 3-year cumulative incidence of conversion to chronic limb-threatening ischemia (33.3% vs 23.8%; P < 0.001), repeat PVI (41.0% vs 38.2%; P < 0.01), and amputation (8.1% vs 2.8%; P < 0.001). After risk adjustment, patients undergoing infrapopliteal PVI had a higher risk of conversion to chronic limb-threatening ischemia [adjusted hazard ratio (aHR): 1.39, 95% CI: 1.25-1.53], repeat PVI (aHR: 1.10, 95% CI: 1.01-1.19), and amputation (aHR: 2.18, 95% CI: 1.77-2.67). Findings were consistent after adjusting for competing risk of death, in a 1:1 propensity-matched analysis, and in subgroup analyses stratified by TASC disease, diabetes, and end-stage kidney disease.
conclusionsInfrapopliteal PVI is associated with worse long-term outcomes than femoropopliteal PVI for claudication. These risks should be discussed with patients.
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Registered trials
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