Evidence map›Paper›PMID 38841818›Full record

ArticleBritish journal of haematology2024

The impact of sickle cell disease and its treatment on ovarian reserve in reproductive-aged Black women.

Lisa M Shandley, Ross M Fasano, Jessica B Spencer, Ann C Mertens, Laura J McPherson, Meredith A Dixon, Natalie Poliektov, Hailly E Butler, Sonjile M James, Penelope P Howards

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisa M ShandleyDivision of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-1443-3651
Ross M FasanoDepartment of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapy, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-8692-4041
Jessica B SpencerDivision of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Ann C MertensDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Laura J McPhersonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Meredith A DixonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Natalie PoliektovDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Hailly E ButlerDepartment of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapy, Emory University School of Medicine, Atlanta, Georgia, USA.
Sonjile M JamesDepartment of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapy, Emory University School of Medicine, Atlanta, Georgia, USA.
Penelope P HowardsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Funding

A Population-Based Study of Fertility in Female Survivors of Young Adult CancerR01HD066059 · NICHD · EMORY UNIVERSITY · PI HOWARDS, PENELOPE P. · 2010 to 2014
$3.1M
Reproductive Health of Young Adult Women Who Have Sickle Cell DiseaseR21HD103030 · NICHD · EMORY UNIVERSITY · PI HOWARDS, PENELOPE P. · 2020 to 2021
$429k
Division of Loan Repayment #1L50HD110031-01NICHD NIH HHS L50 HD110031NICHD NIH HHS R01 HD066059NICHD NIH HHS R21 HD103030
6 · The paper itself

Abstract

We compared serum anti-Mullerian hormone (AMH) levels in women with sickle cell disease (SCD) (n = 152) to those of Black comparison women (n = 128) between the ages of 20 and 45 years and evaluated the impact of hydroxyurea (HU) and iron overload on ovarian reserve in those with SCD. SCD treatment was abstracted from medical records. Linear regression models were fit to examine the relationship between log(AMH) and SCD, adjusting for age. The analysis was repeated to account for HU use (current, previous, never) and iron overload (ferritin ≥1000 ng/mL vs. <1000 ng/mL). AMH estimates among women with SCD were lower than those among comparison women (2.23, 95% confidence interval [CI] 1.80-2.76 vs. 4.12, 95% CI 3.11-5.45, respectively). Women with SCD who were currently using HU had 63% lower (95% CI 43-76) AMH values than comparison women; those with SCD with prior or no HU use also had lower AMH estimates than comparison women, but the difference was less pronounced. There were no differences in predicted AMH values among women with SCD for those with and without iron overload. Women with SCD and low AMH may have a shorter reproductive window and may benefit from referral to a reproductive specialist.

Indexed as

Anemia, Sickle CellAnti-Mullerian HormoneHydroxyureaOvarian ReserveAdultBlack or African AmericanFemaleHumansIron OverloadMiddle AgedYoung AdultAnti-Mullerian HormoneHydroxyureablood transfusionhydroxyureairon overloadovarian reservesickle cell disease

Identifiers

PMID38841818
PMCPMC11315638

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.