Evidence map›Paper›PMID 38841745›Full record

ArticleActa biochimica et biophysica Sinica2024

Up-regulation of miR-10a-5p expression inhibits the proliferation and differentiation of neural stem cells by targeting

Juan Zhang, Lihong Yang, Yuqing Sun, Li Zhang, Yufei Wang, Ming Liu, Xiujuan Li, Yuxiang Liang, Hong Zhao, Zhizhen Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juan ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Lihong YangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Yuqing SunDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Li ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Yufei WangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Ming LiuDepartment of Cell Biology and Genetics, School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, China.
Xiujuan LiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Yuxiang LiangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Hong ZhaoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Zhizhen LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.
Zhiyong QiuBeijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
Ting ZhangBeijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China.
Jun XieDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural tube defects (NTDs) are characterized by the failure of neural tube closure during embryogenesis and are considered the most common and severe central nervous system anomalies during early development. Recent microRNA (miRNA) expression profiling studies have revealed that the dysregulation of several miRNAs plays an important role in retinoic acid (RA)-induced NTDs. However, the molecular functions of these miRNAs in NTDs remain largely unidentified. Here, we show that miR-10a-5p is significantly upregulated in RA-induced NTDs and results in reduced cell growth due to cell cycle arrest and dysregulation of cell differentiation. Moreover, the cell adhesion molecule L1-like (

Indexed as

Cell Adhesion MoleculesMicroRNAsNeural Stem CellsAnimalsCell DifferentiationCell ProliferationCells, CulturedMAP Kinase Signaling SystemMiceNeural Tube DefectsTretinoinUp-RegulationCell Adhesion MoleculesChl1 protein, mouseMicroRNAsMIRN10 microRNA, mouseTretinoincell adhesion molecule L1-like (Chl1)ERK1/2 MAPK signaling pathwaymiR-10a-5pneural tube defectsretinoic acid

Identifiers

PMID38841745
PMCPMC11532229

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.