Evidence map›Paper›PMID 38841651›Full record

ArticleCurrent research in toxicology2024

Insight on cytotoxic NHC gold(I) halide complexes evaluated in multifaceted culture systems.

Vincenza De Gregorio, Alessandra La Pietra, Andrea Candela, Carlo Oliviero, Ida Ferrandino, Diego Tesauro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vincenza De GregorioDepartment of Biology University of Naples "Federico II", Via Cinthia 80126, Napoli, Italy.
Alessandra La PietraDepartment of Biology University of Naples "Federico II", Via Cinthia 80126, Napoli, Italy.
Andrea CandelaDepartment of Biology University of Naples "Federico II", Via Cinthia 80126, Napoli, Italy.
Carlo OlivieroDepartment of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Ida FerrandinoDepartment of Biology University of Naples "Federico II", Via Cinthia 80126, Napoli, Italy.
Diego TesauroDepartment of Pharmacy and Interuniversity Research Centre on Bioactive Peptides (CIRPeB), University of Naples "Federico II", Via Montesano 49, 80131 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold complexes can be a useful system in the fight against cancer. Although many studies have been carried out on in vitro 2D cell culture models embryotoxic assays are particularly lacking. Embryotoxicity and DNA damage are critical concerns in drug development. In this study, the effects of a new N-Heterocyclic carbene (NHC)-Au compound (Bromo[1,3-di-4-methoxybenzyl-4,5-bis(4-methoxyphenyl)imidazol-2-ylidene]gold(I)) at different concentrations were explored using multifaceted approach, encompassing 2D cancer cell cultures,

Indexed as

2D culture systemApoptosisBovine modelEmbryotoxicityNHC-Au complexesZebrafish model

Identifiers

PMID38841651
PMCPMC11152893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.