Factors influencing false-positive results of rifampicin resistance detected by Xpert MTB/RIF: A retrospective study in Zhejiang, China.

Guihua Wu, Jing Wang, Xiaoqun Xu, Hui Wei, Long Cai, Libin Liu

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In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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1 citing paper in PubMed.

A new multiplex molecular assay based on padlock probes and rolling circle amplification for MDR-TB detection in clinical specimens: a prospective diagnostic accuracy study.Therapeutic advances in infectious disease
Article

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5 · Who and what money

Authors and funding

6 authors.

Guihua WuCentre of Laboratory Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.

Jing WangCentre of Laboratory Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.

Xiaoqun XuCentre of Laboratory Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.

Hui WeiCentre of Laboratory Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.

Long CaiCentre of Laboratory Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.

Libin LiuCentre of Laboratory Medicine, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to explore the factors influencing false-positive results for rifampicin resistance (RIF-R) detected using Xpert MTB/RIF (Xpert). Methods: This retrospective analysis included the clinical data of patients from September 2019 to February 2023. The chi-square and rank sum tests were used to compare differences in patient characteristics between the true-positive and false-positive groups. Logistic regression was used to analyze the factors influencing false positives in the detection of RIF-R by Xpert. Results: A total of 384 patients were included. Logistic regression analysis revealed that, with mutation of probe E as the reference, mutations on probe A or C (OR = 72.68, Conclusions: Clinicians should consider factors such as probe mutation type, probe delay, and very low quantification accompanied by probe delay when interpreting Xpert results, which can reduce the misdiagnosis of tuberculosis drug resistance.

Indexed as

Influencing factorsProbe delayProbe mutationRifampicin resistance

Identifiers

PMID38841482

DOI10.1016/j.heliyon.2024.e31680

PMCPMC11152942

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.