ArticleFrontiers in pharmacology2024
Small pouches, but high nicotine doses-nicotine delivery and acute effects after use of tobacco-free nicotine pouches.
Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence-based consensus guidelines for the pharmacological management of substance dependence: Recommendations from the British Association for Psychopharmacology.Journal of psychopharmacology (Oxford, England) · 2026Guideline
- Cardiovascular and metabolic changes following 12 weeks of tobacco and nicotine pouch cessation: a Swedish cohort study.Harm reduction journal · 2025Trial
- Snus, nicotine pouches and cardiovascular disease: Evidence, mechanisms, and the challenge of novel nicotine products.Journal of internal medicine · 2026Review
- Preliminary evaluation of UP2UTeacher, a brief intervention addressing tobacco and nicotine use for high school students.Drug and alcohol dependence · 2026Article
- Oral Nicotine Pouches and Public Health: Evidence from an Updated Scoping Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Nicotine-containing products and the cardiovascular system: mechanisms and global health implications.Nature reviews. Cardiology · 2026Review
- Velo (BAT) buffet of oral nicotine pouches in Pakistan: varying brand variant levels of nicotine, menthol and other flavour chemicals.Tobacco control · 2026Article
- Nicotine Pouch Use and Intentions to Quit Cigarette Smoking Among U.S. Adults.Journal of prevention (2022) · 2026Article
- Effects of nicotine concentration and pH on nicotine pouch appeal and sensory experience: A randomized experimental study.Addiction (Abingdon, England) · 2026Article
- The emerging role of oral nicotine pouches in tobacco harm reduction.Internal and emergency medicine · 2026Review
- Nicotine pouches: an aid in smoking cessation, or a new public health hazard?Internal and emergency medicine · 2026Review
- Article
- Acute Nicotine Poisoning From Nicotine Pouch Use in Adolescents: A Case Report of Two Pediatric Cases.Cureus · 2026Article
- Prevalence of Nicotine Pouch Use Among Youth and Adults in Great Britain-Analysis of Cross-Sectional, Nationally Representative Surveys.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Biomarkers of Exposure to Tobacco-Related Toxicants among Adult Nicotine Pouch Users.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Patterns and Perception of Nicotine Pouches Use Among Adults in Saudi Arabia.Tobacco use insights · 2026Article
- Research on the safety risk of oral nicotine products and its prospects.Current research in toxicology · 2026Review
- Nicotine: evolution, dependence, and the path to total quit: redefining cessation in a changing nicotine landscape.Frontiers in public health · 2026Review
- Photo-Enhanced Nicotine Release From Photosensitive Flavopeptide Derived Supramolecular Gel.Chemistry, an Asian journal · 2026Article
- Reasons to quit cigarettes, e-cigarettes, and smokeless nicotine products: A cross-sectional study among Danish people aged 15-29 years.Tobacco prevention & cessation · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tobacco-free nicotine pouches are new nicotine products for oral consumption. They can contain very high nicotine amounts that have not been addressed with clinical studies yet. Thus, nicotine delivery, effects on craving, and side effects were assessed using pouches with up to 30 mg nicotine. In this single-center, five-arm, crossover study, 15 regular cigarette smokers consumed tobacco-free nicotine pouches from different brands with 6, 20, and 30 mg for 20 min. Comparators were nicotine-free pouches and tobacco cigarettes. At baseline and predefined time points over a study period of 240 min, plasma nicotine concentrations, effects on cigarette craving, and side effects were assessed. Cardiovascular parameters including arterial stiffness were measured using a MobilOGraph. Consumption of 30 mg nicotine pouches has led to a higher nicotine uptake compared with the cigarette (C
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.