Evidence map›Paper›PMID 38841148›Full record

ArticleCerebral circulation - cognition and behavior2024

The protocol for an observational Australian cohort study of CADASIL: The AusCADASIL study.

Danit G Saks, Beata Bajorek, Vibeke S Catts, Adam C Bentvelzen, Jiyang Jiang, Wei Wen, Karen A Mather, Anbupalam Thalamuthu, Jessie Huang-Lung, Lisa Nivison-Smith and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Editorial.Cerebral circulation - cognition and behavior · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Danit G SaksCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Beata BajorekHeart and Stroke Program, Hunter Medical Research Institute, Newcastle, 2305, Australia.
Vibeke S CattsCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Adam C BentvelzenCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Jiyang JiangCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Wei WenCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Karen A MatherCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Jessie Huang-LungSchool of Optometry and Vision Science, University of New South Wales, Sydney, 2052, Australia.
Lisa Nivison-SmithSchool of Optometry and Vision Science, University of New South Wales, Sydney, 2052, Australia.
Lyn R GriffithsGenomics Research Centre, Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, 4059, Australia.
Robert A SmithGenomics Research Centre, Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, 4059, Australia.
Adrienne SextonGenomic Medicine, Royal Melbourne Hospital, Melbourne, 3052, Australia.
Paul JamesGenomic Medicine, Royal Melbourne Hospital, Melbourne, 3052, Australia.
Tharusha JayasenaCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Anne PoljakCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Gurpreet K HansraCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Satoshi HosokiCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Ashley ParkDepartment of Neurology, Royal Melbourne Hospital, Melbourne, 3052, Australia.
Claudia M HillenbrandResearch Imaging NSW, University of New South Wales, Sydney, 2031, Australia.
Peter van WijngaardenCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, 3002, Australia.
Russell J ChanderCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Sam HumphreyDepartment of Neurology, Royal Melbourne Hospital, Melbourne, 3052, Australia.
Rory ChenCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Nicole A KochanCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Tessa J HelmanCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Christopher LeviSchool of Medicine and Public Health, University of Newcastle, Newcastle, 2308, Australia.
Amy BrodtmannDepartment of Neurology, Royal Melbourne Hospital, Melbourne, 3052, Australia.
Michael J O'SullivanInstitute for Molecular Bioscience, University of Queensland, Brisbane, 4067, Australia.
Romesh MarkusDepartment of Neurology, St Vincent's Hospital, Sydney, 2010, Australia.
Ken ButcherDepartment of Neurology, Prince of Wales Hospital, Sydney, 2031, Australia.
Mark ParsonsSchool of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Jason C KovacicSchool of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, 2052, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic condition with a broad phenotypic presentation. This study aims to establish the first Australian cohort of individuals affected by CADASIL (AusCADASIL) and examine its clinical features and longitudinal course, and to investigate neuroimaging and blood biomarkers to assist in early diagnosis and identify disease progression. Methods: Participants will be recruited from six study centres across Australia for an observational study of CADASIL. We aim to recruit 150 participants with diagnosed CADASIL, family history of CADASIL or suspected CADASIL symptoms, and 150 cognitively normal Discussion: AusCADASIL will be the first study of an Australian cohort of individuals with CADASIL. The study will identify common pathogenic variants in this cohort, and characterise the pattern of clinical presentation and longitudinal progression, including imaging features, blood and ocular biomarkers and cognitive profile.

Indexed as

Blood markersCADASILNeuroimagingOcular imagingStudy protocolVascular dementia

Identifiers

PMID38841148
PMCPMC11152887

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.