Evidence map›Paper›PMID 38841099›Full record

ArticleBurns & trauma2024

Immunomodulatory poly(L-lactic acid) nanofibrous membranes promote diabetic wound healing by inhibiting inflammation, oxidation and bacterial infection.

Yan Wu, Jin Zhang, Anqi Lin, Tinglin Zhang, Yong Liu, Chunlei Zhang, Yongkui Yin, Ran Guo, Jie Gao, Yulin Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns & trauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan WuHeilongjiang Key Laboratory of Tissue Damage and Repair, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
Jin ZhangHeilongjiang Key Laboratory of Tissue Damage and Repair, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
Anqi LinThe Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Lingyun Street, Xuhui District, Shanghai 200237, China.
Tinglin ZhangChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, 168 Changhai Road, Yangpu District, Shanghai 200433, China.
Yong LiuScientific Research Sharing Platform, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
Chunlei ZhangScientific Research Sharing Platform, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
Yongkui YinHeilongjiang Key Laboratory of Tissue Damage and Repair, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
Ran GuoDepartment of Physiology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
Jie GaoChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, 168 Changhai Road, Yangpu District, Shanghai 200433, China.ORCID https://orcid.org/0000-0003-1317-2445
Yulin LiThe Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Lingyun Street, Xuhui District, Shanghai 200237, China.
Yanhui ChuHeilongjiang Key Laboratory of Tissue Damage and Repair, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Given the significant impact on human health, it is imperative to develop novel treatment approaches for diabetic wounds, which are prevalent and serious complications of diabetes. The diabetic wound microenvironment has a high level of reactive oxygen species (ROS) and an imbalance between proinflammatory and anti-inflammatory cells/factors, which hamper the healing of chronic wounds. This study aimed to develop poly(L-lactic acid) (PLLA) nanofibrous membranes incorporating curcumin and silver nanoparticles (AgNPs), defined as PLLA/C/Ag, for diabetic wound healing. Methods: PLLA/C/Ag were fabricated via an air-jet spinning approach. The membranes underwent preparation and characterization through various techniques including Fourier-transform infrared spectroscopy, measurement of water contact angle, X-ray photoelectron spectroscopy, X-ray diffraction, scanning electron microscopy, assessment of Results: Loose hydrophilic nanofibrous membranes with uniform fibre sizes were prepared through air-jet spinning. The membranes enabled the efficient and sustained release of curcumin. More importantly, antibacterial AgNPs were successfully reduced Conclusions: In this research, we successfully fabricated PLLA/C/Ag membranes that possess properties of antioxidants, antibacterial agents and anti-inflammatory agents, which can aid in the process of wound healing. Modulating wound inflammation, these new PLLA/C/Ag membranes serve as a novel dressing to enhance the healing of diabetic wounds.

Indexed as

AutophagyBacterialCurcuminDiabetic woundInfectionInflammationNanofibrous membraneOxidationPoly(L-lactic acid)Silver nanoparticlesWound healing

Identifiers

PMID38841099
PMCPMC11151119

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.