Evidence map›Paper›PMID 38840773›Full record

ArticleMedComm2024

Chemoproteomics enables identification of coatomer subunit zeta-1 targeted by a small molecule for enterovirus A71 inhibition.

Xiaoyong Li, Jin Zhang, Yaxin Xiao, Hao Song, Yuexiang Li, Wei Li, Ruiyuan Cao, Song Li, Yong Qin, Chu Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoyong LiKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug, and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University Chengdu China.
Jin ZhangCollege of Chemistry and Molecular Engineering Peking University Beijing China.
Yaxin XiaoKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug, and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University Chengdu China.
Hao SongKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug, and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University Chengdu China.
Yuexiang LiNational Engineering Research Center for the Emergence Drugs Beijing Institute of Pharmacology and Toxicology Beijing China.
Wei LiNational Engineering Research Center for the Emergence Drugs Beijing Institute of Pharmacology and Toxicology Beijing China.
Ruiyuan CaoNational Engineering Research Center for the Emergence Drugs Beijing Institute of Pharmacology and Toxicology Beijing China.
Song LiNational Engineering Research Center for the Emergence Drugs Beijing Institute of Pharmacology and Toxicology Beijing China.
Yong QinKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug, and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University Chengdu China.
Chu WangCollege of Chemistry and Molecular Engineering Peking University Beijing China.
Wu ZhongNational Engineering Research Center for the Emergence Drugs Beijing Institute of Pharmacology and Toxicology Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human enterovirus A71 (EV-A71) is a significant etiological agent responsible for epidemics of hand, foot, and mouth disease (HFMD) in Asia-Pacific regions. There are presently no licensed antivirals against EV-A71, and the druggable target for EV-A71 remains very limited. The phenotypic hit 10,10'-bis(trifluoromethyl) marinopyrrole A derivative, herein termed MPA-CF

Indexed as

chemoproteomicscoatomer subunit zeta‐1enterovirus A71marinopyrrole A derivate

Identifiers

PMID38840773
PMCPMC11151152

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.