Evidence map›Paper›PMID 38840653›Full record

ReviewBiomaterials research2024

Nanodrug Delivery Systems in Antitumor Immunotherapy.

Zishuo Guo, Jinhong Ye, Xuehao Cheng, Tieshan Wang, Yi Zhang, Kaili Yang, Shouying Du, Pengyue Li

Abstract readReview
In one paragraph

Review in Biomaterials research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zishuo GuoBeijing University of Chinese Medicine, Beijing 102488, China.ORCID https://orcid.org/0009-0001-9703-9993
Jinhong YeBeijing University of Chinese Medicine, Beijing 102488, China.ORCID https://orcid.org/0009-0001-3746-7056
Xuehao ChengBeijing University of Chinese Medicine, Beijing 102488, China.ORCID https://orcid.org/0009-0005-0099-8733
Tieshan WangBeijing University of Chinese Medicine, Beijing 102488, China.ORCID https://orcid.org/0009-0001-5088-9165
Yi ZhangYiDu Central Hospital of Weifang, Weifang, Shandong 262500, China.ORCID https://orcid.org/0009-0006-5319-7865
Kaili YangBeijing University of Chinese Medicine, Beijing 102488, China.ORCID https://orcid.org/0009-0004-5074-5817
Shouying DuBeijing University of Chinese Medicine, Beijing 102488, China.ORCID https://orcid.org/0009-0003-9703-0205
Pengyue LiBeijing University of Chinese Medicine, Beijing 102488, China.ORCID https://orcid.org/0009-0001-1848-5857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer has become one of the most important factors threatening human health, and the global cancer burden has been increasing rapidly. Immunotherapy has become another clinical research hotspot after surgery, chemotherapy, and radiotherapy because of its high efficiency and tumor metastasis prevention. However, problems such as lower immune response rate and immune-related adverse reaction in the clinical application of immunotherapy need to be urgently solved. With the development of nanodrug delivery systems, various nanocarrier materials have been used in the research of antitumor immunotherapy with encouraging therapeutic results. In this review, we mainly summarized the combination of nanodrug delivery systems and immunotherapy from the following 4 aspects: (a) nanodrug delivery systems combined with cytokine therapy to improve cytokines delivery in vivo; (b) nanodrug delivery systems provided a suitable platform for the combination of immune checkpoint blockade therapy with other tumor treatments; (c) nanodrug delivery systems helped deliver antigens and adjuvants for tumor vaccines to enhance immune effects; and (d) nanodrug delivery systems improved tumor treatment efficiency and reduced toxicity for adoptive cell therapy. Nanomaterials chosen by researchers to construct nanodrug delivery systems and their function were also introduced in detail. Finally, we discussed the current challenges and future prospects in combining nanodrug delivery systems with immunotherapy.

Identifiers

PMID38840653
PMCPMC11045275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.