ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Review
- Review
- Engineering seed-specific gossypol-free cotton for human-safe consumption by harnessing the dominant-negative effect of the GlPlant communications · 2026Article
- Robustness in jasmonate signaling: mechanisms of concerted regulation and implications for crop improvement.aBIOTECH · 2025Review
- Isolation and Characterization of Two Monoterpene Synthases and a Sesquiterpene Synthase fromMetabolites · 2025Article
- Article
- An HDG11-mediated transcriptional network regulates 1-deoxynojirimycin biosynthesis in mulberry.Plant physiology · 2025Article
- A dirigent protein redirects extracellular terpenoid metabolism for defense against biotic challenges.Nature communications · 2025Article
- The Role of MYC2 Transcription Factors in Plant Secondary Metabolism and Stress Response Mechanisms.Plants (Basel, Switzerland) · 2025Review
- AaMYC3 bridges the regulation of glandular trichome density and artemisinin biosynthesis in Artemisia annua.Plant biotechnology journal · 2025Article
- Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
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Abstract
Plants have evolved diverse defense mechanisms encompassing physical and chemical barriers. Cotton pigment glands are known for containing various defense metabolites, but the precise regulation of gland size to modulate defense compound levels remains enigmatic. Here, it is discovered that the VQ domain-containing protein JAVL negatively regulates pigment gland size and the biosynthesis of defense compounds, while the MYC2-like transcription factor GoPGF has the opposite effect. Notably, GoPGF directly activates the expression of JAVL, whereas JAVL suppresses GoPGF transcription, establishing a negative feedback loop that maintains the expression homeostasis between GoPGF and JAVL. Furthermore, it is observed that JAVL negatively regulates jasmonate levels by inhibiting the expression of jasmonate biosynthetic genes and interacting with GoPGF to attenuate its activation effects, thereby maintaining homeostatic regulation of jasmonate levels. The increased expression ratio of GoPGF to JAVL leads to enlarged pigment glands and elevated jasmonates and defense compounds, enhancing insect and pathogen resistance in cotton. These findings unveil a new mechanism for regulating gland size and secondary metabolites biosynthesis, providing innovative strategies for strengthening plant defense.
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