New 3-Hydroxypyridine-4-one Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and

Sara Sadeghian, Fateme Zare, Lotfollah Saghaie, Afshin Fassihi, Pooria Zare, Razieh Sabet

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Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Sara SadeghianDepartment of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Fateme ZareDepartment of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Lotfollah SaghaieDepartment of Medicinal Chemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Afshin FassihiDepartment of Medicinal Chemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Pooria ZareStudents Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Razieh SabetDepartment of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

Shiraz University of Medical Sciences 29636

6 · The paper itself

Abstract

introductionDrug resistance to existing antimicrobial drugs has become a serious threat to human health, which highlights the need to develop new antimicrobial agents.

methodsIn this study, a new set of 3-hydroxypyridine-4-one derivatives (6a-j) was synthesized, and the antimicrobial effects of these derivatives were evaluated against a variety of microorganisms using the microdilution method. The antimicrobial evaluation indicated that compound 6c, with an electron-donating group -OCH

resultsThe

conclusionThe obtained biological results offer valuable insights into the design of more effective antimicrobial agents.

Indexed as

Candida albicansMicrobial Sensitivity TestsMolecular Docking SimulationStaphylococcus aureusAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsAspergillus nigerEscherichia coliMolecular StructurePyridinesPyridonesStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsPyridinesPyridones3-hydroxypyridine-4-oneADME prediction.antibacterialantifungalmolecular docking studySynthesis

Identifiers

PMID38840401

DOI10.1016/j.ejmech.2016.09.040

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.