Evidence map›Paper›PMID 38840400›Full record

ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2025

Efficient Synthesis of Mannopyranoside-based Fatty Acyl Esters: Effects of Acyl Groups on Antimicrobial Potential.

Md Lutfor Rahaman, Md Atiqur Rahman, Md Mohin Hasnain, Mohammad Amran, Talha Bin Emran, Md Ashikur Rahaman Khan, Md Abdul Majed Patwary, Mohsin Kazi, Mohammed Mahbubul Matin

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Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Md Lutfor RahamanBioorganic and Medicinal Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.ORCID 0000-0001-9897-1267
Md Atiqur RahmanBioorganic and Medicinal Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.ORCID 0000-0002-7563-8450
Md Mohin HasnainBioorganic and Medicinal Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.ORCID 0000-0002-3710-8934
Mohammad AmranBioorganic and Medicinal Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.ORCID 0009-0006-2856-2103
Talha Bin EmranDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.ORCID 0000-0003-3188-2272
Md Ashikur Rahaman KhanBioorganic and Medicinal Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.
Md Abdul Majed PatwaryDepartment of Chemistry, Comilla University, Cumilla, 3506, Bangladesh.ORCID 0000-0003-4680-957X
Mohsin KaziDepartment of Pharmaceutics, College of Pharmacy, PO BOX 2457, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID 0000-0002-5611-0378
Mohammed Mahbubul MatinBioorganic and Medicinal Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, 4331, Bangladesh.

Funding

King Saud University, Riyad, Saudi Arabia RSP2025R301
6 · The paper itself

Abstract

backgroundThe approval of Sucrose Fatty Acid Esters (SFAEs) as food additives/ preservatives with antimicrobial potential has triggered enormous interest in discovering new biological applications. Accordingly, many researchers reported that SFAEs consist of various sugar moieties, and hydrophobic side chains are highly active against certain fungal species.

objectiveThis study aimed to conduct aregioselective synthesis of SAFE and check the effect of chain length and site of acylation (i.e., C-6 vs. C-2, C-3, C-4, and long-chain vs. short-chain) on antimicrobial potency.

methodsA direct acylation method maintaining several conditions was used for esterification.

results

conclusionThis study thus highlights the importance of the acylation site and lipid-like fatty acid chain length that govern the antimicrobial activity of mannopyranoside-based SFAE.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsEstersFatty AcidsMannoseAcylationAspergillusMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsEstersFatty AcidsMannoseADMETantimicrobial agentseffects of chain lengthmolecular dockingregioselective acylationstructureactivity relationshipsugar fatty acid ester (SFAE).

Identifiers

PMID38840400

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.