Evidence map›Paper›PMID 38840223›Full record

ArticleBiology direct2024

M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction.

Hongzhou Guo, Zeya Li, Bin Xiao, Rongchong Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology direct, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hongzhou GuoDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong'an Road, Beijing, 100050, P. R. China.
Zeya LiDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong'an Road, Beijing, 100050, P. R. China.
Bin XiaoDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong'an Road, Beijing, 100050, P. R. China.
Rongchong HuangDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong'an Road, Beijing, 100050, P. R. China. rchuang@ccmu.edu.cn.

Funding

National Natural Science Foundation of China 82270351
6 · The paper itself

Abstract

backgroundMyocardial infarction (MI) is a major cause of mortality and morbidity worldwide. The intercellular communication in post-infarction angiogenesis remains unclear.

methodsIn this study, we explored the role and mechanism of action of M2 macrophage-derived exosomes (M2-exos) in angiogenesis after MI. M2-exos were harvested and injected intramyocardially at the onset of MI. Two distinct endothelial cells (ECs) were cultured with M2-exos to explore the direct effects on angiogenesis.

resultsWe showed that M2-exos improved cardiac function, reduced infarct size, and enhanced angiogenesis after MI. Moreover, M2-exos promoted angiogenesis in vitro; the molecules loaded in the vesicles were responsible for its proangiogenic effects. We further validated that higher abundance of miR-132-3p in M2-exos, which recapitulate their functions, was required for the cardioprotective effects exerted by M2-exos. Mechanistically, miR-132-3p carried by M2-exos down-regulate the expression of THBS1 through direct binding to its 3´UTR and the proangiogenic effects of miR-132-3p were largely reversed by THBS1 overexpression.

conclusionOur findings demonstrate that M2-exos promote angiogenesis after MI by transporting miR-132-3p to ECs, and by binding to THBS1 mRNA directly and negatively regulating its expression. These findings highlight the role of M2-exos in cardiac repair and provide novel mechanistic understanding of intercellular communication in post-infarction angiogenesis.

Indexed as

ExosomesMacrophagesMicroRNAsMyocardial InfarctionNeovascularization, PhysiologicAngiogenesisAnimalsEndothelial CellsHumansMaleMiceMice, Inbred C57BLThrombospondin 1MicroRNAsThrombospondin 1AngiogenesisExosomesM2 macrophagesMyocardial infarction

Identifiers

PMID38840223
PMCPMC11155164

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.