Evidence map›Paper›PMID 38840221›Full record

ArticleJournal of nanobiotechnology2024

ZNPs reduce epidermal mechanical strain resistance by promoting desmosomal cadherin endocytosis via mTORC1-TFEB-BLOC1S3 axis.

Xuan Lai, Menglei Wang, Zhen Zhang, Suya Chen, Xiner Tan, Wenjing Liu, Huimin Liang, Li Li, Longquan Shao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sex and Gender Dimensions in Hazard and Risk Assessment of Engineered Nanomaterials.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuan LaiStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510515, China.
Menglei WangNanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhen ZhangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510515, China.
Suya ChenHospital of Stomatology, Guanghua school of Stomatology, Sun Yat-sen University, Guangzhou, 510080, China.
Xiner TanStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510515, China.
Wenjing LiuStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510515, China.
Huimin LiangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510515, China.
Li LiNanfang Hospital, Southern Medical University, Guangzhou, 510515, China. npfklily@smu.edu.cn.
Longquan ShaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510515, China. shaolongquan@smu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2021A1515111059China Postdoctoral Science Foundation 2021M701617Medical Scientific Research Foundation of Guangdong Province A2022109National Natural Science Foundation of China 82203897Natural Science Foundation of Guangdong Province 2023A1515010204Scientific Research Talent Cultivation Project of Stomatological Hospital, Southern Medical University P2021006Scientific Research Talent Cultivation Project of Stomatological Hospital, Southern Medical University RC202104
6 · The paper itself

Abstract

Zinc oxide nanoparticles (ZNPs) are widely used in sunscreens and nanomedicines, and it was recently confirmed that ZNPs can penetrate stratum corneum into deep epidermis. Therefore, it is necessary to determine the impact of ZNPs on epidermis. In this study, ZNPs were applied to mouse skin at a relatively low concentration for one week. As a result, desmosomes in epidermal tissues were depolymerized, epidermal mechanical strain resistance was reduced, and the levels of desmosomal cadherins were decreased in cell membrane lysates and increased in cytoplasmic lysates. This finding suggested that ZNPs promote desmosomal cadherin endocytosis, which causes desmosome depolymerization. In further studies, ZNPs were proved to decrease mammalian target of rapamycin complex 1 (mTORC1) activity, activate transcription factor EB (TFEB), upregulate biogenesis of lysosome-related organelle complex 1 subunit 3 (BLOC1S3) and consequently promote desmosomal cadherin endocytosis. In addition, the key role of mTORC1 in ZNP-induced decrease in mechanical strain resistance was determined both in vitro and in vivo. It can be concluded that ZNPs reduce epidermal mechanical strain resistance by promoting desmosomal cadherin endocytosis via the mTORC1-TFEB-BLOC1S3 axis. This study helps elucidate the biological effects of ZNPs and suggests that ZNPs increase the risk of epidermal fragmentation.

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsCadherinsEndocytosisEpidermisMechanistic Target of Rapamycin Complex 1Zinc OxideAnimalsDesmosomesMiceNanoparticlesStress, MechanicalBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCadherinsMechanistic Target of Rapamycin Complex 1Tcfeb protein, mouseZinc OxideDesmosomeEpidermisFragmentationZinc oxide nanoparticles

Identifiers

PMID38840221
PMCPMC11151536

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.