Evidence map›Paper›PMID 38840181›Full record

ArticleMolecular brain2024

Dendritic spine head diameter is reduced in the prefrontal cortex of progranulin haploinsufficient mice.

Anna K Cook, Kelsey M Greathouse, Phaedra N Manuel, Noelle H Cooper, Juliana M Eberhardt, Cameron D Freeman, Audrey J Weber, Jeremy H Herskowitz, Andrew E Arrant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna K CookCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kelsey M GreathouseCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Phaedra N ManuelCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Noelle H CooperCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Juliana M EberhardtCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Cameron D FreemanCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Audrey J WeberCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jeremy H HerskowitzCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Andrew E ArrantCenter for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. andrewarrant@uabmc.edu.ORCID 0000-0003-4706-9411

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Identifying therapeutic targets that confer synaptic resilience to Alzheimer's diseaseR01AG061800 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christopher A. Gaiteri, Jeremy H. Herskowitz · 2018 to 2026
$6.9M
Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN MutationsR01NS128031 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Andrew Emmett Arrant · 2022 to 2026
$2.1M
Targeting Rho Kinases for Alzheimer's disease TherapeuticsR01AG054719 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HERSKOWITZ, JEREMY H. · 2017 to 2021
$1.9M
UAB Training Program In NeuroscienceT32NS095775 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erik D Roberson · 2017 to 2026
$1.6M
Synaptic Resilience to Tau in Alzheimer's DiseaseR21AG085379 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HERSKOWITZ, JEREMY H. · 2024 to 2025
$401k
Interactions between progranulin insufficiency and TDP-43F30AG085889 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Anna K Cook · 2024 to 2026
$140k
Tau-mediated synaptic dysfunction in age-related neurodegenerative diseasesF99AG083305 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEBER, AUDREY · 2023 to 2024
$81k
NIA NIH HHS F30 AG085889NIA NIH HHS F30AG085889NIA NIH HHS F99 AG083305NIA NIH HHS F99AG083305NIA NIH HHS R01 AG054719NIA NIH HHS R01AG054719NIA NIH HHS R01 AG061800NIA NIH HHS R01AG061800NIA NIH HHS R21 AG085379NIGMS NIH HHS T32 GM008361NIGMS NIH HHS T32GM008361NINDS NIH HHS R01 NS128031NINDS NIH HHS R01NS128031NINDS NIH HHS T32 NS095775NINDS NIH HHS T32NS095775
6 · The paper itself

Abstract

Loss-of-function mutations in the progranulin (GRN) gene are an autosomal dominant cause of Frontotemporal Dementia (FTD). These mutations typically result in haploinsufficiency of the progranulin protein. Grn

Indexed as

Dendritic SpinesHaploinsufficiencyPrefrontal CortexProgranulinsAnimalsMaleMiceMice, Inbred C57BLPyramidal CellsProgranulinsDendritic spinesFrontotemporal DementiaPrefrontal cortexProgranulinSocial dominance

Identifiers

PMID38840181
PMCPMC11155153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.